脂肪酶抑制剂脂抑素的支链类似物的生物合成起源。
Biosynthetic origin of a branched chain analogue of the lipase inhibitor, lipstatin.
作者信息
Eisenreich Wolfgang, Kupfer Ernst, Stohler Peter, Weber Wolfgang, Bacher Adelbert
机构信息
Lehrstuhl für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Federal Republic of Germany.
出版信息
J Med Chem. 2003 Sep 11;46(19):4209-12. doi: 10.1021/jm030780x.
PMID:12954074
Abstract
The lipophilic beta-lactone, lipstatin, inhibits pancreatic lipase and has been shown earlier to be biosynthesized by Claisen condensation of two fatty acid moieties. We present data from incorporation experiments with [U-13C6]leucine showing that a branched chain analogue of lipstatin is biosynthesized from leucine.
摘要
亲脂性β-内酯利普他汀可抑制胰脂肪酶，且先前已表明它是由两个脂肪酸部分通过克莱森缩合反应生物合成的。我们展示了用[U-¹³C₆]亮氨酸进行掺入实验的数据，结果表明利普他汀的一种支链类似物是由亮氨酸生物合成的。
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