Levy-Marchal C, Tichet J, Fajardy I, Dubois F, Czernichow P
Hôpital Robert Debré, Paris.
Ann Endocrinol (Paris). 1992;53(3):82-5.
Risk factors for IDD have been studied in relatives of patients, in whom the risk is far higher than in the children from the background population. Several factors have been identified as the genetic background at the HLA level (DR and DQ regions) and autoantibodies like islet cells antibodies (ICA) and insulin autoantibodies (IAA). 8,363 sera from schoolchildren (age 6-17 yr) have been tested for the presence of ICA. 150 sera (1.8%) were found positive; the prevalence rate of high ICA titres (> or = 20 uJDF) was very low: 0.2%. ICA titres remained stable over a 8 mth follow-up period. IAA have been measured on the first 2,000 sera and the prevalence rate was 1.2%. Only 3 sera were found positive for the two antibodies, one coming from a diabetic girl. The distribution of the susceptibility alleles at the DQ-HLA region was similar among the ICA-positive and ICA-negative children.
已在患者亲属中研究了自身免疫性糖尿病（IDD）的危险因素，这些亲属患该病的风险远高于普通人群中的儿童。已确定几个因素为HLA水平（DR和DQ区域）的遗传背景以及自身抗体，如胰岛细胞抗体（ICA）和胰岛素自身抗体（IAA）。已对8363名学童（6 - 17岁）的血清进行了ICA检测。发现150份血清（1.8%）呈阳性；高ICA滴度（≥20 uJDF）的患病率非常低：0.2%。在8个月的随访期内，ICA滴度保持稳定。已对最初的2000份血清进行了IAA检测，患病率为1.2%。仅发现3份血清两种抗体均呈阳性，其中一份来自一名糖尿病女孩。DQ - HLA区域易感性等位基因的分布在ICA阳性和ICA阴性儿童中相似。
