Préziosi Marie-Pierre, Halloran M Elizabeth
Niakhar Project, Institut de Recherche pour le Développement, Dakar, Senegal.
Clin Infect Dis. 2003 Sep 15;37(6):772-9. doi: 10.1086/377270. Epub 2003 Aug 23.
We estimated the effectiveness of pertussis vaccination in reducing the clinical severity of breakthrough disease among vaccinated individuals from a comprehensive follow-up study of a community of 30,000 residents of Niakhar, Senegal, in 1993. A physician examined all children with potential pertussis (cough of >7 days' duration). Samples were collected from 97% of these children for culture or serologic testing as part of the active surveillance for a pertussis vaccine trial. Cases of pertussis were defined by confirmation through culture or serologic testing or by a history of contact with a person with culture-confirmed pertussis. Among children with confirmed cases, severity of illness was assessed according to a scale that combined clinical signs and symptoms. The efficacy of the vaccine in reducing disease severity was 48% (95% confidence interval, 39%-55%) among children vaccinated with 3 doses of whole-cell (67%) or acellular (32%) vaccine. Primary cases were more severe than secondary cases in residential compounds. Pertussis vaccination is effective in reducing the severity of illness.
1993年，我们在塞内加尔尼亚喀尔一个拥有3万居民的社区开展了一项全面的随访研究，评估百日咳疫苗在降低接种疫苗个体中突破性疾病临床严重程度方面的有效性。一名医生检查了所有疑似百日咳（咳嗽持续超过7天）的儿童。作为百日咳疫苗试验主动监测的一部分，从97%的此类儿童中采集样本进行培养或血清学检测。百日咳病例通过培养或血清学检测确诊，或根据与培养确诊的百日咳患者接触史确定。在确诊病例的儿童中，根据综合临床体征和症状的量表评估疾病严重程度。在接种3剂全细胞（67%）或无细胞（32%）疫苗的儿童中，疫苗降低疾病严重程度的效力为48%（95%置信区间，39%-55%）。在居住区内，原发性病例比继发性病例更严重。百日咳疫苗在降低疾病严重程度方面是有效的。
