一例人用有机磷杀虫剂倍硫磷故意中毒病例的观察
Observation on a human intentional poisoning case by the organophosphorus insecticide fenthion.
作者信息
Brunetto M R, Burguera J L, Burguera M, Villegas F, Bastidas C
机构信息
Department of Chemistry, Faculty of Sciences, University of Los Andes, Mérida, Venezuela.
出版信息
Invest Clin. 1992;33(3):89-94.
A case of acute poisoning by oral ingestion of fenthion is reported. Plasma cholinesterase activity and fenthion whole blood concentration were thoroughly evaluated during the therapeutic intervention that consisted in administration of atropine, toxogonine and fresh plasma. Correlation studies between clinical signs, cholinesterase activity and fenthion levels revealed that pChE activity was not as helpful as the patient's clinical status in determining when the atropine infusion could be stopped. Moreover pChE was also useless in signaling sudden relapses. It is concluded, based on this case, that supportive care combined with antidotal therapy remains the cornerstone of treatment specially in severe acute poisoning cases.
报告了1例口服倍硫磷急性中毒病例。在给予阿托品、解磷定和新鲜血浆的治疗干预过程中，对血浆胆碱酯酶活性和倍硫磷全血浓度进行了全面评估。临床体征、胆碱酯酶活性和倍硫磷水平之间的相关性研究表明，在确定何时可以停止输注阿托品时，血浆胆碱酯酶（pChE）活性不如患者的临床状态有用。此外，pChE在提示突然复发方面也毫无用处。基于该病例得出结论，支持性护理与解毒治疗相结合仍然是治疗的基石，特别是在严重急性中毒病例中。
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