Tsatsakis A M, Aguridakis P, Michalodimitrakis M N, Tsakalov A K, Alegakis A K, Koumantakis E, Troulakis G
Laboratory of Toxicology, School of Medicine, University of Crete, Greece.
Vet Hum Toxicol. 1996 Apr;38(2):101-7.
Nine human acute poisonings due to intentional ingestion of organophosphorous pesticides are presented. Six of the victims died. Six patients were treated in the Intensive Care Unit (ICU) from 34 h to 45 d, while 3 were found dead by relatives. Two of the patients treated in the ICU fully recovered after 15 and 24 d while the third survivor developed delayed neuropathy. Organophosphate blood levels were determined on admission and during therapy, and in 1 case atropine and pralidoxime levels were also detected. Significant fluctuations of the plasma cholinesterase activity were observed during therapy. Postmortem analysis revealed higher levels of pesticides in organs (eg 23.1 micrograms fenthion/g kidney) and in fat (135.2 micrograms fenthion/g) than in blood (eg 4.8 micrograms fenthion/ml) and vitreous humor. Considerable pesticide was measured in testis (eg 5.8 micrograms fenthion/g, 0.8 micrograms methidathion/g) and uterus (170.5 micrograms malathion/g). Extracorporeal decontamination to enhance pesticide elimination is a therapeutic challenge.
本文介绍了9起因故意摄入有机磷农药导致的人体急性中毒事件。其中6名受害者死亡。6名患者在重症监护病房（ICU）接受了34小时至45天的治疗，另外3名患者被亲属发现死亡。在ICU接受治疗的2名患者分别于15天和24天后完全康复，第三名幸存者出现了迟发性神经病变。在入院时和治疗期间测定了有机磷血药浓度，1例还检测了阿托品和氯解磷定的血药浓度。治疗期间观察到血浆胆碱酯酶活性有显著波动。尸检分析显示，器官（如23.1微克倍硫磷/克肾脏）和脂肪（135.2微克倍硫磷/克）中的农药含量高于血液（如4.8微克倍硫磷/毫升）和玻璃体液。在睾丸（如5.8微克倍硫磷/克、0.8微克杀扑磷/克）和子宫（170.5微克马拉硫磷/克）中检测到相当量的农药。通过体外净化来加强农药清除是一项治疗挑战。
