上皮迁移：关注c-Jun蛋白。
Epithelial migration: open your eyes to c-Jun.
作者信息
Grose Richard
机构信息
Viral Carcinogenesis Laboratory, Cancer Research UK London Research Institute, 61 Lincoln's Inn Fields, WC2A 3PX, London, UK.
出版信息
Curr Biol. 2003 Sep 2;13(17):R678-80. doi: 10.1016/s0960-9822(03)00607-9.
Abstract
Tissue-specific removal of c-jun from epidermal cells in mice leads to a failure of eyelid fusion during embryogenesis and reveals roles for c-Jun in wound repair and tumorigenesis in adult skin. This has provided a definitive test of the in vivo function of AP-1 signalling and shown that EGF signalling is key to all of c-Jun's roles in the epidermis.
摘要
在小鼠表皮细胞中特异性去除c-jun会导致胚胎发育过程中眼睑融合失败，并揭示了c-Jun在成年皮肤伤口修复和肿瘤发生中的作用。这为AP-1信号通路的体内功能提供了决定性测试，并表明表皮生长因子（EGF）信号是c-Jun在表皮中所有作用的关键。
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