Schächinger Hartmut, Cox Daniel, Linder Lilly, Brody Stuart, Keller Ulrich
Division of Psychosomatic Medicine, BIM, University Hospital, Petersgraben 4, 4031 Basel, Switzerland.
Pharmacol Biochem Behav. 2003 Jul;75(4):915-20. doi: 10.1016/s0091-3057(03)00167-9.
Hypoglycemia has been shown to impair cognitive and psychomotor function, but it has been unclear which measures are most reliable and sensitive for detecting these effects. In a single-blind repeated measures design, healthy young adults (N=17, 8 male, mean age 27 years) performed three PC-based cognitive and psychomotor function tests: a paced auditory serial addition task (PASAT), an adaptive five-choice reaction time test (CRTT), and a manual tracking test on two occasions 4 weeks apart. In each session, a hyperinsulinemic clamp method was used during a normoglycemic (plasma glucose: 4.7 mmol/l) baseline testing period, followed in one session by a normoglycemic target testing period, and in the other session by a hypoglycemic (2.7 mmol/l) target testing period. All cognitive and psychomotor function measures showed high test-retest reliability (r ranging from.69 to.95) and sensitivity to hypoglycemia (P<.01). A new finding is that on the PASAT, hypoglycemia appears to differentially increase the rate of omission errors more than it increases false responses. Data on PASAT reaction time (RT) are also presented.
低血糖已被证明会损害认知和心理运动功能，但尚不清楚哪些测量方法对检测这些影响最为可靠和敏感。在一项单盲重复测量设计中，健康的年轻成年人（N = 17，8名男性，平均年龄27岁）进行了三项基于电脑的认知和心理运动功能测试：定速听觉连续加法任务（PASAT）、自适应五选择反应时测试（CRTT）以及手动跟踪测试，测试在相隔4周的两个时间段进行。在每个时间段中，在正常血糖（血浆葡萄糖：4.7 mmol/L）基线测试期采用高胰岛素钳夹法，随后在一个时间段进行正常血糖目标测试期，在另一个时间段进行低血糖（2.7 mmol/L）目标测试期。所有认知和心理运动功能测量均显示出高重测信度（r范围为0.69至0.95）以及对低血糖的敏感性（P < 0.01）。一项新发现是，在PASAT测试中，低血糖似乎对漏报错误率的增加幅度大于对错误反应的增加幅度。还呈现了PASAT反应时（RT）的数据。
