Rotstein O D
Department of Surgery, Toronto General Hospital, Ontario, Canada.
Eur J Clin Microbiol Infect Dis. 1992 Nov;11(11):1064-8. doi: 10.1007/BF01967800.
The production of fibrinous exudates plays an important role in determining the outcome of peritoneal infection. Large numbers of bacteria are sequestered within fibrin matrices, thereby retarding bacterial spread throughout the peritoneal cavity and into the bloodstream. This walling-off process is teleologically advantageous in that it lessens early rapid mortality. Recent studies have documented that this same process is probably integral to the development of residual infection in the peritoneum. Bacteria sequestered within fibrin deposits are protected from normal host clearance mechanisms, thereby permitting unopposed proliferation and ultimately the establishment of an abscess. A complete understanding of the cellular and noncellular aspects of the host response to peritoneal infection will suggest novel strategies both to treat and to prevent the development of intraabdominal abscesses and their attendant consequences.
纤维蛋白性渗出物的产生在决定腹膜感染的结局中起重要作用。大量细菌被隔离在纤维蛋白基质内，从而延缓细菌在整个腹腔内的扩散并进入血液。这种隔离过程在目的论上是有利的，因为它降低了早期的快速死亡率。最近的研究表明，同样的过程可能是腹膜残余感染发展所不可或缺的。隔离在纤维蛋白沉积物中的细菌免受正常宿主清除机制的影响，从而允许其无阻碍地增殖并最终形成脓肿。全面了解宿主对腹膜感染的细胞和非细胞方面的反应将为治疗和预防腹腔脓肿的形成及其相关后果提供新的策略。
