坦桑尼亚西北部的生殖道人乳头瘤病毒基因型
Genital human papillomavirus genotypes in northwestern Tanzania.
作者信息
Mayaud Philippe, Weiss Helen A, Lacey Charles J N, Gill Dilbinder K, Mabey David C W
机构信息
Department of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, United Kingdom.
出版信息
J Clin Microbiol. 2003 Sep;41(9):4451-3. doi: 10.1128/JCM.41.9.4451-4453.2003.
Abstract
Using MY09-MY11 PCR and human papillomavirus (HPV) typing by reverse blot hybridization, we found a 34% cervical HPV prevalence among 561 pregnant women in Tanzania. One hundred three of 123 women (84%) with typeable samples harbored high-risk oncogenic strains. HPV type 16 (HPV-16) was the most prevalent subtype (18%) among HPV-infected women and among women with cervical neoplasia (3 of 19). A multivalent vaccine for HPV-16, -18, -31, -33, and -35 would be necessary to prevent 50% of the neoplasia in this population.
摘要
通过MY09 - MY11聚合酶链反应（PCR）和反向斑点杂交进行人乳头瘤病毒（HPV）分型，我们发现坦桑尼亚561名孕妇的宫颈HPV感染率为34%。在123名可分型样本的女性中，有103名（84%）携带高危致癌菌株。HPV 16型（HPV - 16）是HPV感染女性以及宫颈肿瘤女性中最常见的亚型（18%，19例中有3例）。一种针对HPV - 16、 - 18、 - 31、 - 33和 - 35的多价疫苗对于预防该人群中50%的肿瘤是必要的。
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