Xie Yong, Duan Yu-Bin, Xu Jian-Xue, Kang Yan-Mei, Hu San-Jue
State Key Laboratory of Mechanical Structural Strength and Vibration, Xi'an Jiaotong University, China.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Sep;35(9):806-10.
A specific bursting, parabolic bursting induced by veratridine, has been observed in rat injured sciatic nerve. With the help of Plant model, the biophysical mechanism for such a phenomenon is revealed from the viewpoint of nonlinear dynamical theory. The slow sodium influx educed by veratridine and the calcium-dependent potassium outflux are regarded as the two slow variables, which are responsible for the parabolic bursting. Furthermore, the roles that veratridine plays in the emergence of the parabolic bursting, namely inhibiting the inactivation of sodium channels and eliciting the slow sodium influx, are clarified.
在大鼠坐骨神经损伤模型中，观察到了由藜芦碱诱导的一种特定的爆发性放电，即抛物线型爆发放电。借助于普兰特模型，从非线性动力学理论的角度揭示了这种现象的生物物理机制。由藜芦碱引起的缓慢钠内流和钙依赖性钾外流被视为两个慢变量，它们导致了抛物线型爆发放电。此外，还阐明了藜芦碱在抛物线型爆发放电出现过程中所起的作用，即抑制钠通道失活并引发缓慢钠内流。
