Iwasa K
Physiol Chem Phys. 1982;14(6):503-12.
Swelling of crab claw nerve fibers, monitored as weight increase, takes place while the nerve fibers are immersed in a medium high in K+, Cs+ or Rb+ concentration, or in artificial seawater to which 0.2 mM veratridine is added. Similar swelling is observed in nerves in sodium salt solutions which also contain low concentrations of divalent cations. The swelling observed under these conditions is dependent on anions, giving a series (from efficient anion to less efficient ones): I- greater than SCN- greater than Br- greater than Cl- much greater than F- greater than glutamate, ethylsulfate. The presence of this series indicates that the nerve swelling observed is attributed to influx of external salt. Uptake measurements of radioactive anions and cations corroborate the presence of salt influx under these conditions. In analyzing the anion dependence of nerve swelling, two factors, membrane and cytoskeletal structure, are examined. It is shown that the cytoskeletal structure, which is sensitive to the lyotropic series of anions, plays an important role in this phenomenon.
蟹爪神经纤维的肿胀，通过重量增加来监测，发生在神经纤维浸入钾离子、铯离子或铷离子浓度高的介质中，或添加了0.2 mM藜芦碱的人工海水中时。在同样含有低浓度二价阳离子的钠盐溶液中的神经中也观察到类似的肿胀。在这些条件下观察到的肿胀依赖于阴离子，形成一个系列（从有效的阴离子到效果较差的阴离子）：碘离子大于硫氰酸根离子大于溴离子大于氯离子远大于氟离子大于谷氨酸根离子、硫酸乙酯。这个系列的存在表明观察到的神经肿胀归因于外部盐分的流入。放射性阴离子和阳离子的摄取测量证实了在这些条件下盐分流入的存在。在分析神经肿胀对阴离子的依赖性时，研究了两个因素，即膜和细胞骨架结构。结果表明，对阴离子的离液序列敏感的细胞骨架结构在这一现象中起重要作用。
