Hahn-Zoric M, Hytönen A M, Hanson L A, Nilsson L A, Padyukov L
Department of Clinical Immunology, University of Göteborg, Göteborg, Sweden.
J Clin Immunol. 2003 Jul;23(4):291-6. doi: 10.1023/a:1024588800754.
Coeliac disease (CD) is known to have a strong genetic background. We analyzed the association between serological markers of CD and the -1087 IL10 and -308 TNFA gene polymorphisms in Swedish patients. A higher frequency of the TNF2 allele was present in the patients compared with the controls (p < 0.0001). The frequency of the AA genotype of the IL10 gene in the patients was unexpectedly higher in comparison with the controls (p < 0.05). The levels of IgA anti-endomysium and antitissue transglutaminase antibodies were associated with IL10 but not with TNFA genotype. The patients with the AA or GG -1087 IL10 genotypes had significantly lower levels of antibodies in comparison with those with the AG genotype (p < 0.05 to p < 0.0005). However, when divided according to potential level of IL-10 production, the group of potentially high IL-10 producers among the CD patients demonstrated significantly lower levels of antitissue transglutaminase antibodies compared to potentially low IL-10 producers (p = 0.01). Our results show a relationship between the levels of IgA antibodies involved in CD with the IL10 genotypes. This suggests a possible involvement of IL-10 in the development of the disease.
乳糜泻（CD）具有很强的遗传背景。我们分析了瑞典患者中CD的血清学标志物与-1087 IL10和-308 TNFA基因多态性之间的关联。与对照组相比，患者中TNF2等位基因的频率更高（p < 0.0001）。与对照组相比，患者中IL10基因AA基因型的频率意外地更高（p < 0.05）。IgA抗肌内膜和抗组织转谷氨酰胺酶抗体水平与IL10相关，但与TNFA基因型无关。与AG基因型患者相比，AA或GG -1087 IL10基因型患者的抗体水平显著更低（p < 0.05至p < 0.0005）。然而，根据潜在的IL-10产生水平进行划分时，CD患者中潜在高IL-10产生者组的抗组织转谷氨酰胺酶抗体水平明显低于潜在低IL-10产生者组（p = 0.01）。我们的结果表明，参与CD的IgA抗体水平与IL10基因型之间存在关联。这表明IL-10可能参与了该疾病的发展。
