Padyukov L, Hahn-Zoric M, Lau Y L, Hanson L A
Department of Clinical Immunology, University of Göteborg, Guldhedsgatan 10A, 413 46, Göteborg, Sweden.
Genes Immun. 2001 Aug;2(5):280-3. doi: 10.1038/sj.gene.6363771.
It has been shown that cytokine gene polymorphisms are important in the regulation of the level of cytokine production that may affect the development and extent of inflammatory diseases and transplant rejections. The frequency of the -308 TNFA, -383 TNFR1, -1087 IL10 and codon 25 TGFB1 alleles were analysed in two different ethnic groups: Chinese from Hong Kong and Caucasians from western Sweden. Significant differences in the occurrence of the analysed alleles were shown between the two populations. The most profound difference was found in the frequency of the A/A genotype at the -1087 position of IL10 gene (18% in Caucasians and 89% in Chinese, P < 0.0001, both for the genotype and allele frequencies) and less although statistically significant for other investigated genes. The noted differences in the frequency of functionally important alleles of cytokine genes may have consequences for the mode of appearance and outcome of certain diseases in individuals of different ethnicity.
研究表明，细胞因子基因多态性在调节细胞因子产生水平方面很重要，这可能会影响炎症性疾病和移植排斥反应的发展及程度。对两个不同种族群体分析了-308 TNFA、-383 TNFR1、-1087 IL10和密码子25 TGFB1等位基因的频率：来自中国香港的中国人和来自瑞典西部的高加索人。两个群体之间分析的等位基因出现频率存在显著差异。在IL10基因-1087位点的A/A基因型频率上发现了最显著的差异（高加索人为18%，中国人为89%，基因型和等位基因频率的P均<0.0001），其他研究基因的差异虽较小但具有统计学意义。细胞因子基因功能重要等位基因频率的显著差异可能会对不同种族个体某些疾病的表现方式和结局产生影响。
