The effect of substitution on anticonvulsant activity of some 5,5-diphenylhydantoin derivatives.
作者信息
Lange J, Lapszewicz J
机构信息
Department of Technology and Biotechnology of Pharmaceutical Products, Institute of Organic Technology, Technical University, Warsaw.
出版信息
Acta Pol Pharm. 1990;47(1-2):31-4.
PMID:12959256
Abstract
Some 5,5-diarylhydantoins and their 3-amino derivatives were synthesized as phenytoin analogs with enhanced rotational restriction of the benzene moieties. In preliminary pharmacological tests, the compounds symmetrically substituted in the benzene rings proved practically inactive as anticonvulsants. High and prolonged activity was observed with 3-amino-5,5-diphenylhydantoin.
摘要
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