Campbell N R, Wickert W A, Shumak S L
Foothills Hospital and Divisions of Geriatrics and Internal Medicine, Departments of Medicine, Pharmacology and Therapeutics, Cardiovascular Research Group, Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada.
Br J Clin Pharmacol. 1993 Dec;36(6):607-9. doi: 10.1111/j.1365-2125.1993.tb00423.x.
In a randomized double-blind placebo controlled parallel study involving fourteen healthy male volunteers, we examined whether the acute reduction in vascular volume associated with frusemide ingestion would haemoconcentrate lipid particles. Three hours after a single 40 mg oral dose of frusemide, there were 9.6-14.4% increases in lipids and lipoproteins which were highly correlated to changes in body weight. Until further studies determine the extent of haemoconcentration in patients being treated long term with frusemide, we recommend that blood be drawn for lipid analysis prior to frusemide ingestion.
在一项涉及14名健康男性志愿者的随机双盲安慰剂对照平行研究中，我们研究了与服用速尿相关的血管容量急性减少是否会使脂质颗粒发生血液浓缩。单次口服40毫克速尿三小时后，脂质和脂蛋白增加了9.6%-14.4%，这与体重变化高度相关。在进一步研究确定长期接受速尿治疗的患者血液浓缩程度之前，我们建议在服用速尿之前采集血液进行脂质分析。
