Ginsberg H N
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
Endocrinol Metab Clin North Am. 1990 Jun;19(2):211-28.
The major plasma lipids, cholesterol, triglycerides, and phospholipids are transported as components of macromolecular complexes called lipoproteins. The major lipoprotein classes include the chylomicrons, which transport dietary lipids to the peripheral tissues and the liver; very low density and low density lipoproteins, which transport endogenously synthesized lipids from the liver to peripheral tissues; and high density lipoproteins, which appear to facilitate the reverse transport of cholesterol from peripheral tissues to the liver. The rates of synthesis and catabolism of the major lipoprotein classes are regulated, to a large degree, by one or more proteins, called apoproteins, that reside on the surface of the lipoproteins. This article describes normal lipoprotein metabolism and includes discussions of the role of abnormalities in lipoprotein transport in the atherogenic process.
主要的血浆脂质，即胆固醇、甘油三酯和磷脂，作为称为脂蛋白的大分子复合物的组成成分进行运输。主要的脂蛋白类别包括乳糜微粒，它将膳食脂质运输到外周组织和肝脏；极低密度脂蛋白和低密度脂蛋白，它们将肝脏内源性合成的脂质运输到外周组织；以及高密度脂蛋白，它似乎有助于胆固醇从外周组织逆向运输到肝脏。主要脂蛋白类别的合成和分解代谢速率在很大程度上受一种或多种称为载脂蛋白的蛋白质调节，这些蛋白质存在于脂蛋白表面。本文描述了正常的脂蛋白代谢，并讨论了脂蛋白运输异常在动脉粥样硬化过程中的作用。
