吸烟会加快奎宁的排泄。
Cigarette smoking enhances the elimination of quinine.
作者信息
Wanwimolruk S, Wong S M, Coville P F, Viriyayudhakorn S, Thitiarchakul S
机构信息
School of Pharmacy, University of Otago, Dunedin, New Zealand.
出版信息
Br J Clin Pharmacol. 1993 Dec;36(6):610-4. doi: 10.1111/j.1365-2125.1993.tb00424.x.
The pharmacokinetics of a single dose (600 mg) of quinine sulphate were examined in a group of non-smokers (n = 10) and in heavy cigarette smokers (n = 10). The mean (+/- s.d.) oral clearance of quinine in smokers (0.189 +/- 0.075 1 h(-1) kg(-1)) was significantly greater than in non-smokers (0.107 +/- 0.045 1 h(-1) kg(-1) , P < 0.01). The unbound clearance of quinine which reflects activity of the drug-metabolizing enzyme, was considerably greater (1.5-fold) in the smokers than in the non-smoker subjects. The mean elimination half-life of quinine in smokers was 7.5 +/- 1.4 (s.d.) h, significantly shorter (P < 0.005) than the mean value in non-smokers (12.0 +/- 3.1 h). These results suggest that cigarette smoking enhances the elimination of quinine. The clinical significance of these findings is unknown but they indicate the need for caution in the administration of quinine to patients who are heavy cigarette smokers.
在一组不吸烟者（n = 10）和重度吸烟者（n = 10）中研究了单剂量（600毫克）硫酸奎宁的药代动力学。吸烟者中奎宁的平均（±标准差）口服清除率（0.189±0.075升/小时·千克）显著高于不吸烟者（0.107±0.045升/小时·千克，P < 0.01）。反映药物代谢酶活性的奎宁非结合清除率在吸烟者中比不吸烟者高得多（1.5倍）。吸烟者中奎宁的平均消除半衰期为7.5±1.4（标准差）小时，明显短于不吸烟者的平均值（12.0±3.1小时，P < 0.005）。这些结果表明吸烟会增强奎宁的消除。这些发现的临床意义尚不清楚，但它们表明在给重度吸烟者使用奎宁时需要谨慎。
Zotero 插件