van der Lei B, Bartels H L, Robinson P H, Bakker W W
Department of Plastic and Reconstructive Surgery, University Hospital of Groningen, The Netherlands.
Int Angiol. 1992 Oct-Dec;11(4):268-71.
In this pilot study ADP-ase coated polyurethane (PU) vascular prostheses and noncoated (control) PU vascular prostheses (all vascular prostheses: ID 1.5 mm, length 1.5 cm) were implanted into the carotid artery of the rabbit to test whether ADP-ase might function as an adequate anti-thrombogenic coating. The prostheses were evaluated after 1 hour (n = 4) and 3 weeks (n = 8). After 1 hour, there was extensive accumulation of thrombus on the inner surface of the control PU vascular prostheses, in contrast to the ADP-ase coated prostheses. At 3 weeks, all control PU vascular prostheses (n = 8) were occluded, whereas only 1 of the 8 ADP-ase coated PU vascular prostheses. The patient ADP-ase coated PU prostheses showed already extensive endothelial healing. These results indicate the potential of ADP-ase to function as an effective antithrombogenic coating of small-caliber and microvascular PU prostheses.
在这项初步研究中，将二磷酸腺苷酶（ADP-ase）包被的聚氨酯（PU）血管假体和未包被（对照）的PU血管假体（所有血管假体：内径1.5毫米，长度1.5厘米）植入兔颈动脉，以测试ADP-ase是否可作为一种合适的抗血栓形成涂层。在1小时（n = 4）和3周（n = 8）后对假体进行评估。1小时后，对照PU血管假体的内表面有大量血栓积聚，而ADP-ase包被的假体则相反。3周时，所有对照PU血管假体（n = 8）均被阻塞，而8个ADP-ase包被的PU血管假体中只有1个被阻塞。患者使用的ADP-ase包被的PU假体已显示出广泛的内皮愈合。这些结果表明，ADP-ase有潜力作为小口径和微血管PU假体的有效抗血栓形成涂层。
