Kawanishi H, Shiraishi M, Igarashi Y, Takeshima T, Toyohara S, Imai S, Shimamura K, Maruden A
Imamichi Institute for Animal Reproduction, Ibaraki, Japan.
J Toxicol Sci. 1992 Dec;17 Suppl 4:231-52. doi: 10.2131/jts.17.supplementiv_231.
A postnatal study of F1 offspring exposed to FUT-187 during fetal organogenesis was carried out using Crj : CD rat. FUT-187 was dosed by gavage at 0, 50, 200 and 800 mg/kg/day from day 7 to 17 of gestation. All pregnant rats were allowed to deliver newborns, and F1 offspring were examined for development indices and reproduction and learning ability. Effects at 800 mg/kg included temporary salivation, body weight depression and decreased food intake. There were no adverse effects on delivery and lactation and no significant changes on neonatal development, growth, reproduction and learning ability in the F1 offspring. These results indicate that the no effect dose level of FUT-187 is 200 mg/kg/day in dams, and 800 mg/kg/day in offspring.
使用Crj:CD大鼠对在胎儿器官形成期暴露于FUT-187的F1代后代进行了一项产后研究。在妊娠第7天至17天，通过灌胃给予FUT-187，剂量分别为0、50、200和800毫克/千克/天。所有怀孕大鼠均正常分娩，对F1代后代的发育指标、生殖和学习能力进行了检查。800毫克/千克剂量的影响包括暂时流涎、体重减轻和食物摄入量减少。对分娩和哺乳没有不良影响，F1代后代的新生儿发育、生长、生殖和学习能力也没有显著变化。这些结果表明，FUT-187对母鼠的无作用剂量水平为200毫克/千克/天，对后代为800毫克/千克/天。
