Shimamura K, Terazawa K, Terabayashi M, Watanabe K, Hasegawa N, Kuramoto S, Yokomoto Y, Otani K, Maruden A
Research Laboratories, Torii & Co., Ltd., Chiba, Japan.
J Toxicol Sci. 1992 Dec;17 Suppl 4:221-30. doi: 10.2131/jts.17.supplementiv_221.
6-Amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187) was given orally to pregnant Crj : CD (Sprague-Dawley) rats from days 7 through 17 of gestation at dose levels of 50, 200 and 800 mg/kg/day. In the 800 mg/kg/day group, salivation just after dosing, suppression in body weight gain and decreased food consumption were observed. No external, visceral and skeletal anomalies attributable to FUT-187 were observed in fetuses. From the present result, it is considered that the no-effect dose level of FUT-187 for dams and fetuses are 200 mg/kg/day and 800 mg/kg/day respectively.
在妊娠第7天至17天，给妊娠的Crj:CD（斯普拉格-道利）大鼠口服6-脒基-2-萘基4-[(4,5-二氢-1H-咪唑-2-基)氨基]苯甲酸酯二甲磺酸盐（FUT-187），剂量水平分别为50、200和800mg/kg/天。在800mg/kg/天组中，给药后出现流涎、体重增加抑制和食物消耗减少的情况。在胎儿中未观察到归因于FUT-187的外部、内脏和骨骼异常。根据目前的结果，认为FUT-187对母鼠和胎儿的无作用剂量水平分别为200mg/kg/天和800mg/kg/天。
