Gutjahr P, Jung H
Laryngol Rhinol Otol (Stuttg). 1975 Apr;54(4):297-308.
In treating childhood lymphosarcoma, high-dose combination chemotherapy is most effective, when given as long-term therapy. The most important advances of the therapeutic regimen described here are not only obtaining complete remissions but to have them maintained; the side-effects of the intensive therapy are well to be kept under control. Besides, some of the drugs are effective against the severe complications, leucemic transformation and sacromatous meningiosis. The median time of complete remission in our own patients with head and neck primaries is already 63 weeks; in comparison, that of a former group of children was 11 weeks.
在治疗儿童淋巴肉瘤时，大剂量联合化疗作为长期治疗最为有效。此处所述治疗方案最重要的进展不仅在于实现完全缓解，还在于维持缓解状态；强化治疗的副作用也应得到良好控制。此外，某些药物对严重并发症、白血病转化和肉瘤性脑膜炎有效。我们自己治疗的头颈部原发性患者的完全缓解中位时间已达63周；相比之下，前一组儿童的完全缓解中位时间为11周。
