自然杀伤细胞在体内不会被卡波西肉瘤相关疱疹病毒感染，且自然杀伤细胞计数与患卡波西肉瘤的风险无关。

Natural killer cells are not infected by Kaposi's sarcoma-associated herpesvirus in vivo, and natural killer cell counts do not correlate with the risk of developing Kaposi's sarcoma.

作者信息

Stebbing Justin, Gazzard Brian, Flore Ornella, Thomas Claire, Benlahrech Adel, Mandalia Sundhiya, Bower Mark, Gotch Frances, Patterson Steve

机构信息

Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London SW10 9NH, UK.

出版信息

AIDS. 2003 Sep 5;17(13):1998-2000. doi: 10.1097/01.aids.0000088168.01779.01.

DOI:10.1097/01.aids.0000088168.01779.01

PMID:12960839

Abstract

Although the innate immune system is implicated in the control of Kaposi's sarcoma (KS), the risk of developing KS is not associated with the nadir natural killer (NK) cell count, and NK cell counts do not significantly increase or decrease during KS resolution. KS-associated herpesvirus replication was not demonstrated in vivo or in vitro within NK cells, suggesting that NK cells do not contribute to the resolution of KS. Their role appears limited to events occurring during early infection.

摘要

尽管固有免疫系统与卡波西肉瘤（KS）的控制有关，但患KS的风险与自然杀伤（NK）细胞计数的最低点无关，并且在KS消退期间NK细胞计数没有显著增加或减少。在NK细胞内未在体内或体外证实与KS相关的疱疹病毒复制，这表明NK细胞对KS的消退没有作用。它们的作用似乎仅限于早期感染期间发生的事件。