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自然杀伤细胞在体内不会被卡波西肉瘤相关疱疹病毒感染，且自然杀伤细胞计数与患卡波西肉瘤的风险无关。

Natural killer cells are not infected by Kaposi's sarcoma-associated herpesvirus in vivo, and natural killer cell counts do not correlate with the risk of developing Kaposi's sarcoma.

作者信息

Stebbing Justin, Gazzard Brian, Flore Ornella, Thomas Claire, Benlahrech Adel, Mandalia Sundhiya, Bower Mark, Gotch Frances, Patterson Steve

机构信息

Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London SW10 9NH, UK.

出版信息

AIDS. 2003 Sep 5;17(13):1998-2000. doi: 10.1097/01.aids.0000088168.01779.01.

DOI:10.1097/01.aids.0000088168.01779.01
PMID:12960839
Abstract

Although the innate immune system is implicated in the control of Kaposi's sarcoma (KS), the risk of developing KS is not associated with the nadir natural killer (NK) cell count, and NK cell counts do not significantly increase or decrease during KS resolution. KS-associated herpesvirus replication was not demonstrated in vivo or in vitro within NK cells, suggesting that NK cells do not contribute to the resolution of KS. Their role appears limited to events occurring during early infection.

摘要

尽管固有免疫系统与卡波西肉瘤（KS）的控制有关，但患KS的风险与自然杀伤（NK）细胞计数的最低点无关，并且在KS消退期间NK细胞计数没有显著增加或减少。在NK细胞内未在体内或体外证实与KS相关的疱疹病毒复制，这表明NK细胞对KS的消退没有作用。它们的作用似乎仅限于早期感染期间发生的事件。

相似文献

1
Natural killer cells are not infected by Kaposi's sarcoma-associated herpesvirus in vivo, and natural killer cell counts do not correlate with the risk of developing Kaposi's sarcoma.自然杀伤细胞在体内不会被卡波西肉瘤相关疱疹病毒感染，且自然杀伤细胞计数与患卡波西肉瘤的风险无关。
AIDS. 2003 Sep 5;17(13):1998-2000. doi: 10.1097/01.aids.0000088168.01779.01.
2
NK cell activity controls human herpesvirus 8 latent infection and is restored upon highly active antiretroviral therapy in AIDS patients with regressing Kaposi's sarcoma.自然杀伤细胞活性控制人类疱疹病毒8型潜伏感染，且在艾滋病相关卡波西肉瘤消退的艾滋病患者接受高效抗逆转录病毒治疗后得以恢复。
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Monitoring of endogenous interferon-alpha and human herpesvirus 8 in HIV-infected patients with Kaposi's sarcoma.对感染人类免疫缺陷病毒且患有卡波西肉瘤的患者体内内源性α干扰素和人类疱疹病毒8的监测。
Eur J Med Res. 2002 Jan 29;7(1):19-24.
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Kaposi's sarcoma-associated herpesvirus-specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C-infected individuals with Kaposi's sarcoma.卡波西肉瘤相关疱疹病毒特异性免疫重建以及高效抗逆转录病毒治疗/化疗联合方案对感染C型HIV且患有卡波西肉瘤个体的抗病毒作用
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Seroreactivity to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) latent nuclear antigen in AIDS-associated Kaposi's sarcoma patients depends on CD4+ T-cell count.艾滋病相关卡波西肉瘤患者对卡波西肉瘤相关疱疹病毒（人疱疹病毒8型）潜伏核抗原的血清反应性取决于CD4+T细胞计数。
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Control of human herpes virus type 8-associated diseases by NK cells.自然杀伤细胞对人8型疱疹病毒相关疾病的控制。
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Long-term clinical outcome of AIDS-related Kaposi's sarcoma during highly active antiretroviral therapy.高效抗逆转录病毒治疗期间艾滋病相关卡波西肉瘤的长期临床结局
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HHV-8 DNA in blood and the development of HIV-associated Kaposi's sarcoma in the era of HAART--a prospective evaluation.高效抗逆转录病毒治疗时代血液中HHV-8 DNA与HIV相关卡波西肉瘤的发生——一项前瞻性评估
Eur J Med Res. 2002 Jun 28;7(6):283-6.
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[Diagnosis and treatment of HIV-related Kaposi's sarcoma].[人类免疫缺陷病毒相关卡波西肉瘤的诊断与治疗]
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Retrospective, longitudinal analysis of serum human herpesvirus-8 viral DNA load in AIDS-related Kaposi's sarcoma patients before and after diagnosis.对艾滋病相关卡波西肉瘤患者诊断前后血清人疱疹病毒8型病毒DNA载量进行回顾性纵向分析。
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引用本文的文献

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Prospects for NK Cell Therapy of Sarcoma.肉瘤自然杀伤细胞疗法的前景
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2
Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma.人类疱疹病毒 8 型（HHV8）在无症状感染和卡波西肉瘤的过程中依次塑造 NK 细胞库。
PLoS Pathog. 2012 Jan;8(1):e1002486. doi: 10.1371/journal.ppat.1002486. Epub 2012 Jan 12.
3
NKG2C+ NK cells are enriched in AIDS patients with advanced-stage Kaposi's sarcoma.
NKG2C+自然杀伤细胞在患有晚期卡波西肉瘤的艾滋病患者中富集。
J Virol. 2007 Jan;81(1):430-3. doi: 10.1128/JVI.01567-06. Epub 2006 Oct 11.
4
Highly active anti-retroviral therapy (HAART)-induced maintenance of adaptive but not innate immune parameters is associated with protection from HIV-induced mortality.高效抗逆转录病毒疗法（HAART）诱导的适应性而非先天性免疫参数的维持与预防HIV诱导的死亡相关。
Clin Exp Immunol. 2006 Aug;145(2):271-6. doi: 10.1111/j.1365-2249.2006.03147.x.
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KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice.在NOD/SCID小鼠长期的增殖性感染过程中，卡波西肉瘤相关疱疹病毒（KSHV）靶向多种白细胞谱系。
J Clin Invest. 2006 Jul;116(7):1963-73. doi: 10.1172/JCI27249. Epub 2006 Jun 22.
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J Infect Dis. 2006 Apr 15;193(8):1051-3. doi: 10.1086/501475. Epub 2006 Mar 6.