NKG2C+自然杀伤细胞在患有晚期卡波西肉瘤的艾滋病患者中富集。
NKG2C+ NK cells are enriched in AIDS patients with advanced-stage Kaposi's sarcoma.
作者信息
Goodier Martin R, Mela C M, Steel A, Gazzard B, Bower M, Gotch F
机构信息
Department of Immunology, Imperial College London, United Kingdom.
出版信息
J Virol. 2007 Jan;81(1):430-3. doi: 10.1128/JVI.01567-06. Epub 2006 Oct 11.
Abstract
Kaposi's sarcoma (KS) is an AIDS-defining condition in individuals with human immunodeficiency virus type 1 infection. We investigated the phenotype and function of the NKG2C+ NK cell population in individuals with AIDS and Kaposi's sarcoma. The staging of AIDS KS patients according to the AIDS Clinical Trial Group criteria revealed that patients with the S1 disease stage have a significantly higher proportion of NKG2C+ cells than those with the S0 disease stage. NKG2C+ cells from S1-stage patients are highly enriched for the expression of KIR3DL1, are depleted of NKp46, and respond poorly to major histocompatibility complex class I-positive target cells. These data demonstrate a link between NK cell phenotype and function and disease prognosis in AIDS.
摘要
卡波西肉瘤（KS）是1型人类免疫缺陷病毒感染个体的一种艾滋病定义疾病。我们研究了艾滋病合并卡波西肉瘤患者中NKG2C+自然杀伤（NK）细胞群体的表型和功能。根据艾滋病临床试验组标准对艾滋病KS患者进行分期，结果显示，S1疾病阶段的患者中NKG2C+细胞的比例显著高于S0疾病阶段的患者。S1阶段患者的NKG2C+细胞高度富集KIR3DL1的表达，NKp46表达缺失，对主要组织相容性复合体I类阳性靶细胞反应较差。这些数据表明NK细胞表型和功能与艾滋病疾病预后之间存在联系。
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