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2
NK cell activity controls human herpesvirus 8 latent infection and is restored upon highly active antiretroviral therapy in AIDS patients with regressing Kaposi's sarcoma.自然杀伤细胞活性控制人类疱疹病毒8型潜伏感染，且在艾滋病相关卡波西肉瘤消退的艾滋病患者接受高效抗逆转录病毒治疗后得以恢复。
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Increased NKG2A found in cytotoxic natural killer subset in HIV-1 patients with advanced clinical status.在临床进展期的HIV-1患者的细胞毒性自然杀伤细胞亚群中发现NKG2A增加。
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Paclitaxel for AIDS-associated Kaposi's sarcoma.紫杉醇用于治疗艾滋病相关的卡波西肉瘤。
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Retrospective, longitudinal analysis of serum human herpesvirus-8 viral DNA load in AIDS-related Kaposi's sarcoma patients before and after diagnosis.对艾滋病相关卡波西肉瘤患者诊断前后血清人疱疹病毒8型病毒DNA载量进行回顾性纵向分析。
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Natural killer cells are not infected by Kaposi's sarcoma-associated herpesvirus in vivo, and natural killer cell counts do not correlate with the risk of developing Kaposi's sarcoma.自然杀伤细胞在体内不会被卡波西肉瘤相关疱疹病毒感染，且自然杀伤细胞计数与患卡波西肉瘤的风险无关。
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Control of human herpes virus type 8-associated diseases by NK cells.自然杀伤细胞对人8型疱疹病毒相关疾病的控制。
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Clinical and immunological follow-up of patients with AIDS-associated Kaposi's sarcoma treated with an anti-IL-6 monoclonal antibody.
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NKG2C is a major triggering receptor involved in the V[delta]1 T cell-mediated cytotoxicity against HIV-infected CD4 T cells.NKG2C是一种主要的触发受体，参与V[δ]1 T细胞介导的针对HIV感染的CD4 T细胞的细胞毒性作用。
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Genetic Causes of Human NK Cell Deficiency and Their Effect on NK Cell Subsets.人类自然杀伤细胞缺陷的遗传原因及其对自然杀伤细胞亚群的影响。
Front Immunol. 2016 Dec 2;7:545. doi: 10.3389/fimmu.2016.00545. eCollection 2016.
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NK Cell Influence on the Outcome of Primary Epstein-Barr Virus Infection.自然杀伤细胞对原发性爱泼斯坦-巴尔病毒感染结局的影响。
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IL-12-producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion.产生白细胞介素-12的单核细胞和HLA-E控制巨细胞病毒驱动的NKG2C+自然杀伤细胞扩增。
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Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry.通过液质联用技术揭示人类 NK 细胞多样性的遗传和环境决定因素。
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本文引用的文献

1
Human cytomegalovirus infection is associated with increased proportions of NK cells that express the CD94/NKG2C receptor in aviremic HIV-1-positive patients.在无病毒血症的HIV-1阳性患者中，人巨细胞病毒感染与表达CD94/NKG2C受体的自然杀伤细胞比例增加有关。
J Infect Dis. 2006 Jul 1;194(1):38-41. doi: 10.1086/504719. Epub 2006 May 24.
2
Structural basis for a major histocompatibility complex class Ib-restricted T cell response.主要组织相容性复合体 Ib 类限制的 T 细胞应答的结构基础。
Nat Immunol. 2006 Mar;7(3):256-64. doi: 10.1038/ni1312. Epub 2006 Feb 12.
3
Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts.CD94/NKG2C+自然杀伤细胞对人巨细胞病毒感染的成纤维细胞的应答性扩增。
Blood. 2006 May 1;107(9):3624-31. doi: 10.1182/blood-2005-09-3682. Epub 2005 Dec 29.
4
NK cells in HIV infection: paradigm for protection or targets for ambush.HIV感染中的自然杀伤细胞：保护范例还是伏击目标。
Nat Rev Immunol. 2005 Nov;5(11):835-43. doi: 10.1038/nri1711.
5
Switch from inhibitory to activating NKG2 receptor expression in HIV-1 infection: lack of reversion with highly active antiretroviral therapy.
AIDS. 2005 Nov 4;19(16):1761-9. doi: 10.1097/01.aids.0000183632.12418.33.
6
Shared alterations in NK cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis C virus infections.慢性人类免疫缺陷病毒和丙型肝炎病毒感染中自然杀伤细胞频率、表型和功能的共同改变。
J Virol. 2005 Oct;79(19):12365-74. doi: 10.1128/JVI.79.19.12365-12374.2005.
7
The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells.CD94/NKG2C杀伤性凝集素样受体构成了一部分CD8+T细胞的另一种激活途径。
Eur J Immunol. 2005 Jul;35(7):2071-80. doi: 10.1002/eji.200425843.
8
Interaction between KIR3DL1 and HLA-B*57 supertype alleles influences the progression of HIV-1 infection in a Zambian population.KIR3DL1与HLA - B*57超型等位基因之间的相互作用影响赞比亚人群中HIV - 1感染的进程。
Hum Immunol. 2005 Mar;66(3):285-9. doi: 10.1016/j.humimm.2005.01.001.
9
NK cell recognition.自然杀伤细胞识别
Annu Rev Immunol. 2005;23:225-74. doi: 10.1146/annurev.immunol.23.021704.115526.
10
Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals.CD56-/CD16+自然杀伤（NK）细胞的特征：在HIV感染的病毒血症个体中扩增的高度功能失调的NK亚群。
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2886-91. doi: 10.1073/pnas.0409872102. Epub 2005 Feb 7.

NKG2C+自然杀伤细胞在患有晚期卡波西肉瘤的艾滋病患者中富集。

NKG2C+ NK cells are enriched in AIDS patients with advanced-stage Kaposi's sarcoma.

作者信息

Goodier Martin R, Mela C M, Steel A, Gazzard B, Bower M, Gotch F

机构信息

Department of Immunology, Imperial College London, United Kingdom.

出版信息

J Virol. 2007 Jan;81(1):430-3. doi: 10.1128/JVI.01567-06. Epub 2006 Oct 11.

DOI:10.1128/JVI.01567-06
PMID:17035308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1797234/
Abstract

Kaposi's sarcoma (KS) is an AIDS-defining condition in individuals with human immunodeficiency virus type 1 infection. We investigated the phenotype and function of the NKG2C+ NK cell population in individuals with AIDS and Kaposi's sarcoma. The staging of AIDS KS patients according to the AIDS Clinical Trial Group criteria revealed that patients with the S1 disease stage have a significantly higher proportion of NKG2C+ cells than those with the S0 disease stage. NKG2C+ cells from S1-stage patients are highly enriched for the expression of KIR3DL1, are depleted of NKp46, and respond poorly to major histocompatibility complex class I-positive target cells. These data demonstrate a link between NK cell phenotype and function and disease prognosis in AIDS.

摘要

卡波西肉瘤（KS）是1型人类免疫缺陷病毒感染个体的一种艾滋病定义疾病。我们研究了艾滋病合并卡波西肉瘤患者中NKG2C+自然杀伤（NK）细胞群体的表型和功能。根据艾滋病临床试验组标准对艾滋病KS患者进行分期，结果显示，S1疾病阶段的患者中NKG2C+细胞的比例显著高于S0疾病阶段的患者。S1阶段患者的NKG2C+细胞高度富集KIR3DL1的表达，NKp46表达缺失，对主要组织相容性复合体I类阳性靶细胞反应较差。这些数据表明NK细胞表型和功能与艾滋病疾病预后之间存在联系。