Misu Tatsuro, Fujihara Kazuo, Itoyama Yasuto
Division of Neurology, Department of Neurosciences, Tohoku University Graduate School of Medicine.
Nihon Rinsho. 2003 Aug;61(8):1422-7.
Findings of chemokines and chemokine receptors in multiple sclerosis(MS) are reviewed. MS is a T-helper type 1 (Th1) dominant condition, and Th1-associated chemokine receptors(CCR5 and CXCR3) on CD4- and CD8-positive T cells and their ligands are upregulated in the CNS of the patients with active disease. Meanwhile, Th2-associated chemokine receptors(CCR3 and CCR4) on CD4- and CD8-positive T cells are suppressed during relapse. Their expressions are useful immunological measures of disease activity, clinical subtypes and therapy. CCR7 and the ligands are expressed in the CNS of MS and may be important for the recruitment of immune cells committed to immunological memory and antigen presentation.
本文综述了多发性硬化症（MS）中趋化因子和趋化因子受体的研究结果。MS是以1型辅助性T细胞（Th1）为主导的疾病，在活动性疾病患者的中枢神经系统中，CD4和CD8阳性T细胞上与Th1相关的趋化因子受体（CCR5和CXCR3）及其配体上调。同时，在复发期间，CD4和CD8阳性T细胞上与Th2相关的趋化因子受体（CCR3和CCR4）受到抑制。它们的表达是疾病活动、临床亚型和治疗的有用免疫学指标。CCR7及其配体在MS的中枢神经系统中表达，可能对募集致力于免疫记忆和抗原呈递的免疫细胞很重要。
