Teleshova Natalia, Pashenkov Mikhail, Huang Yu-Min, Söderström Mats, Kivisäkk Pia, Kostulas Vasilios, Haglund Mats, Link Hans
Department of Neurology, Karolinska Institutet, Huddinge University Hospital, 14186 Stockholm, Sweden.
J Neurol. 2002 Jun;249(6):723-9. doi: 10.1007/s00415-002-0699-z.
A role for chemokines as mediators of Th1 cell recruitment to the central nervous system (CNS) is probable in MS. Therefore we studied expression of Th1-related CCR5 and CXCR3 chemokine receptors in patients with MS and controls. Patients with untreated MS had elevated percentages of CCR5 and CXCR3 expressing T cells vs. healthy controls (HC) in blood, and vs. other non-inflammatory neurological diseases (OND) patients in CSF. Such elevation was not found in MS patients examined during ongoing treatment with IFN-beta. Patients with optic neuritis (ON), a common first manifestation of MS, had elevated percentages of CXCR3 expressing T cells in blood compared with HC, and of CCR5 expressing T cells in CSF compared with OND patients. High chemokine receptor expression may be one prerequisite for Th1 cells to migrate to the CNS. Inhibition of chemokine receptor expression may constitute a potentially important therapeutic effect of IFN-beta.
趋化因子作为Th1细胞募集至中枢神经系统（CNS）的介质在多发性硬化症（MS）中可能发挥作用。因此，我们研究了MS患者和对照中Th1相关的CCR5和CXCR3趋化因子受体的表达。未经治疗的MS患者血液中表达CCR5和CXCR3的T细胞百分比相对于健康对照（HC）升高，脑脊液中相对于其他非炎性神经疾病（OND）患者升高。在用β-干扰素进行持续治疗的MS患者中未发现这种升高。视神经炎（ON）是MS常见的首发表现，与HC相比，其血液中表达CXCR3的T细胞百分比升高，与OND患者相比，脑脊液中表达CCR5的T细胞百分比升高。高趋化因子受体表达可能是Th1细胞迁移至CNS的一个先决条件。抑制趋化因子受体表达可能构成β-干扰素潜在的重要治疗作用。
