Guleria R, Singh Th Rajendra, Sinha Sanjeev, Padhy K, Gupta K, Pande J N
Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Indian J Chest Dis Allied Sci. 2003 Oct-Dec;45(4):241-6.
Chronic obstructive airway disease (COAD) is associated with hyperplasia and hypertrophy of the mucus producing glands. The beneficial effect of inhaled drug may be due to improved mucociliary function. The present study was done to evaluate the effect of salbutamol, ipratropium bromide and beclomethasone dipropionate inhalation on mucociliary clearance in patients with COAD.
Ten patients of COAD were taken up, two patients however did not complete the study. Salbutamol, ipratropium bromide, beclomethasone dipropionate and placebo inhalation were given randomly to each patient on four separate days. Radioaerosol inhalation lung cine-scintigraphy after inhalation of the different drugs was followed up to two hours and than after 24 hours.
There was no significant visually noticeable increased mucociliary clearance on any of the days. Two patients showed definite steep slope in the time activity curves with salbutamol as compared to other drugs or placebo. All the quantitative indices analysed at the end of one hour and two hours for the three drugs were comparable to placebo.
A single dose of inhaled salbutamol, ipratropium bromide and beclomethasone dipropionate has no appreciable effect on mucociliary clearance in patients with COAD.
慢性阻塞性气道疾病（COAD）与黏液分泌腺的增生和肥大有关。吸入药物的有益作用可能归因于黏液纤毛功能的改善。本研究旨在评估沙丁胺醇、异丙托溴铵和丙酸倍氯米松吸入对COAD患者黏液纤毛清除功能的影响。
选取10例COAD患者，然而有2例患者未完成研究。在四个不同日期，将沙丁胺醇、异丙托溴铵、丙酸倍氯米松和安慰剂吸入剂随机给予每位患者。在吸入不同药物后，进行放射性气溶胶吸入肺动态闪烁扫描，随访2小时，然后在24小时后再次进行扫描。
在任何一天，均未观察到黏液纤毛清除功能有明显的视觉上可察觉的增加。与其他药物或安慰剂相比，有2例患者在使用沙丁胺醇时，时间 - 活性曲线显示出明确的陡坡。在1小时和2小时末对这三种药物分析的所有定量指标均与安慰剂相当。
单剂量吸入沙丁胺醇、异丙托溴铵和丙酸倍氯米松对COAD患者的黏液纤毛清除功能没有明显影响。
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