Mainardi J L, Goldstein F W
Service de microbiologie médicale, hôpital Saint-Joseph, Paris.
Rev Prat. 1992 Nov 15;42(18):2268-70.
The emergence and the increase of antibiotic resistant Salmonella particularly in non-typhi species has occurred in recent years. Beside plasmid mediated resistance, new resistance mechanisms like alterations of permeability have been identified. Factors associated with resistance are the use of antibiotics in human and animals. These findings have important public health implications. It seems necessary to define a more adapted policy in human and veterinary use in order to avoid the rapid emergence of drug-resistance among regularly active antibiotics like fluoroquinolones.
近年来,抗生素耐药性沙门氏菌尤其是非伤寒沙门氏菌出现并增多。除了质粒介导的耐药性外,还发现了新的耐药机制,如通透性改变。与耐药性相关的因素包括人类和动物使用抗生素。这些发现具有重要的公共卫生意义。为避免在氟喹诺酮等常用抗生素中迅速出现耐药性,似乎有必要在人类和兽医用药方面制定更合适的政策。