Schellenberg Roberta S, Tan Ben J K, Irvine James D, Stockdale Donna R, Gajadhar Alvin A, Serhir Bouchra, Botha Juri, Armstrong Cheryl A, Woods Shirley A, Blondeau Joseph M, McNab Tammy L
Department of Internal Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
J Infect Dis. 2003 Sep 15;188(6):835-43. doi: 10.1086/378094. Epub 2003 Sep 9.
In June 2000, bear meat infected with Trichinella nativa was consumed by 78 individuals in 2 northern Saskatchewan communities. Interviews and blood collections were performed on exposed individuals at the onset of the outbreak and 7 weeks later. All exposed individuals were treated with mebendazole or albendazole, and symptomatic patients received prednisone. Confirmed cases were more likely to have consumed dried meat, rather than boiled meat (P<.001). Seventy-four percent of patients completed the recommended therapy, and 87% of patients who were followed up in August 2000 reported complete resolution of symptoms. This outbreak of trichinellosis was caused by consumption of inadequately cooked bear meat contaminated with T. nativa. Apart from clinical symptomatology, blood counts, creatine kinase levels, serology test results, and analysis of the remaining bear meat helped establish the diagnosis. Treatment with antiparasitic drugs and prednisone was beneficial in limiting the severity and duration of the illness.
2000年6月,萨斯喀彻温省北部两个社区的78人食用了感染本地旋毛虫的熊肉。在疫情爆发初期和7周后,对暴露人群进行了访谈和血液采集。所有暴露人群均接受了甲苯达唑或阿苯达唑治疗,有症状的患者接受了泼尼松治疗。确诊病例更有可能食用了干肉,而非煮过的肉(P<0.001)。74%的患者完成了推荐治疗,2000年8月接受随访的患者中有87%报告症状完全缓解。此次旋毛虫病疫情是由食用了被本地旋毛虫污染的未煮熟熊肉引起的。除临床症状外,血细胞计数、肌酸激酶水平、血清学检测结果以及对剩余熊肉的分析有助于确诊。使用抗寄生虫药物和泼尼松进行治疗有助于减轻疾病的严重程度并缩短病程。