Larsen K, Fabrin J, Holstein P E
Diabetes Centre, Copenhagen, Denmark.
J Wound Care. 2001 Sep;10(8):323-8. doi: 10.12968/jowc.2001.10.8.26113.
This study followed 115 patients with diabetes--who between them had 140 feet with Charcot's arthropathy--over six to 114 months (median: 48). A total of 43 patients (37%) developed ulcers in 53 feet. Their treatment was multifactorial. An offloading regimen was adopted, with the use of crutches and therapeutic sandals with soft, individually moulded insoles, followed by adjusted or bespoke shoes. Recalcitrant ulcers were treated with surgery in 16 patients (37%). Antibiotics were needed by 21 patients (49%). The incidence of ulceration was 17% per year. The median time interval between the acute component of Charcot's arthropathy and ulcer development was 36 months (range: 0-120 months). In seven patients, the ulcer developed during the acute phase. In 12 patients the ulcers were localised to the rockerbottom deformity in the mid-foot region, but in 31 patients other regions were affected. Dynamic footprint analysis was used to help adjust the offloading shoe/insole on the rockerbottom deformity. Such ulcers took twice as long to heal as other ulcers. Surgical treatment comprised: major amputation (two patients), arthrodesis for unstable ankle (three patients), toe amputations (seven patients), resection of the rockerbottom deformity (one patient) and other revisions (three patients). One patient died with an unhealed ulcer. There is a four-fold risk of ulcers in diabetic Charcot deformity compared with the overall risk of foot ulcers in diabetic feet. Healing was achieved in 40 patients (93%). The surgical intervention rate of 37% in ulcer cases in Charcot feet was low compared with the literature.
本研究对115例糖尿病患者(他们共有140只患有夏科氏关节病的足部)进行了6至114个月(中位数:48个月)的随访。共有43例患者(37%)的53只足部出现溃疡。他们的治疗是多方面的。采用了减负方案,使用拐杖和带有柔软、个性化定制鞋垫的治疗性凉鞋,随后是调整后的或定制的鞋子。16例患者(37%)的顽固性溃疡接受了手术治疗。21例患者(49%)需要使用抗生素。溃疡发生率为每年17%。夏科氏关节病急性期与溃疡形成之间的中位时间间隔为36个月(范围:0至120个月)。7例患者在急性期出现溃疡。12例患者的溃疡局限于中足区域的摇椅底畸形处,但31例患者的其他区域也受到影响。动态足迹分析用于帮助调整针对摇椅底畸形的减负鞋/鞋垫。此类溃疡愈合所需时间是其他溃疡的两倍。手术治疗包括:大截肢(2例患者)、不稳定踝关节融合术(3例患者)、趾截肢(7例患者)、摇椅底畸形切除术(1例患者)和其他矫正手术(3例患者)。1例患者因溃疡未愈合死亡。与糖尿病足溃疡的总体风险相比,糖尿病夏科氏畸形患者发生溃疡的风险高出四倍。40例患者(93%)实现了愈合。与文献相比,夏科氏足部溃疡病例37%的手术干预率较低。