Fadillioglu Ersin, Yilmaz H Ramazan, Erdogan Hasan, Sogut Sadik
Department of Physiology, Faculty of Medicine, Inonu University, TR 44069, Malatya, Turkey.
Toxicology. 2003 Sep 30;191(2-3):153-8. doi: 10.1016/s0300-483x(03)00258-0.
The aim of this experimental study was to investigate the effects of erdosteine, an antioxidant agent, on doxorubicin (DXR)-induced cardio-toxicity through nitric oxide (NO) levels, collagen synthesis, xanthine oxidase (XO) and adenosine deaminase (ADA) activities in rats. Rats were treated with erdosteine (10 mg/kg b.wt. per day, orally) or saline starting 2 days before administrating a single dose of DXR (20 mg/kg i.p.) or saline. At the 10th day of the DXR administration, hearts were removed under anesthesia for biochemical measurements. Enzyme activities as well as OH-proline and NO levels were found to be significantly increased in DXR group compared with the control group. All of the parameters studied except ADA activity were decreased significantly approximating to the control levels upon erdosteine administration. In conclusion, erdosteine seems to be an alternative agent for protection of cardiac tissue against DXR-induced cardio-toxicity through its regulatory effect on XO activity and NO level.
本实验研究的目的是通过检测大鼠体内一氧化氮（NO）水平、胶原蛋白合成、黄嘌呤氧化酶（XO）和腺苷脱氨酶（ADA）活性，来研究抗氧化剂厄多司坦对阿霉素（DXR）诱导的心脏毒性的影响。在单次腹腔注射阿霉素（20mg/kg）或生理盐水前2天，大鼠分别口服厄多司坦（10mg/kg体重/天）或生理盐水。在注射阿霉素后的第10天，将大鼠麻醉后取出心脏进行生化检测。结果发现，与对照组相比，阿霉素组的酶活性以及羟脯氨酸和NO水平显著升高。给予厄多司坦后，除ADA活性外，所有研究参数均显著降低，接近对照组水平。总之，厄多司坦似乎是一种替代药物，通过对XO活性和NO水平的调节作用，保护心脏组织免受阿霉素诱导的心脏毒性。
