Hübener Mark
Max-Planck-Institut für Neurobiologie, Am Klopferspitz 18A, D-82152 Martinsried, Germany.
Curr Opin Neurobiol. 2003 Aug;13(4):413-20. doi: 10.1016/s0959-4388(03)00102-8.
Neurons in mouse visual cortex have diverse receptive field properties and they respond selectively to specific features of visual stimuli. Owing to the lateral position of the eyes, only about a third of the visual cortex receives input from both eyes, but many cells in this region are binocular. Similar to higher mammals, closing one eye during a critical period shifts the responses of cells, such that they are better driven by the non-deprived eye. In this review I illustrate how the combination of transgenic mouse technology with single cell recording and modern imaging techniques might lead to a further understanding of the mechanisms that underlie the development, plasticity, and function of the mammalian visual cortex.
小鼠视觉皮层中的神经元具有多样的感受野特性，它们对视觉刺激的特定特征有选择性反应。由于眼睛的外侧位置，只有约三分之一的视觉皮层接收来自双眼的输入，但该区域的许多细胞是双眼的。与高等哺乳动物类似，在关键期闭合一只眼睛会改变细胞的反应，使其更好地由未剥夺的眼睛驱动。在这篇综述中，我阐述了转基因小鼠技术与单细胞记录和现代成像技术的结合如何可能进一步理解哺乳动物视觉皮层发育、可塑性和功能背后的机制。
