Alitto Henry J, Usrey W Martin
Center for Neuroscience, University of California, 1544 Newton Court, Davis, CA 95616, USA.
Curr Opin Neurobiol. 2003 Aug;13(4):440-5. doi: 10.1016/s0959-4388(03)00096-5.
Although nearly half of the synaptic input to neurons in the dorsal thalamus comes from the cerebral cortex, the role of corticothalamic projections in sensory processing remains elusive. Although sensory afferents certainly establish the basic receptive field properties of thalamic neurons, increasing evidence indicates that feedback from the cortex plays a crucial role in shaping thalamic responses. Here, we review recent work on the corticothalamic pathways associated with the visual, auditory, and somatosensory systems. Collectively, these studies demonstrate that sensory responses of thalamic neurons result from dynamic interactions between feedforward and feedback pathways.
尽管背侧丘脑神经元近一半的突触输入来自大脑皮层，但皮质丘脑投射在感觉处理中的作用仍不清楚。虽然感觉传入神经肯定确立了丘脑神经元的基本感受野特性，但越来越多的证据表明，来自皮层的反馈在塑造丘脑反应中起关键作用。在这里，我们综述了最近关于与视觉、听觉和体感系统相关的皮质丘脑通路的研究。总的来说，这些研究表明，丘脑神经元的感觉反应是由前馈和反馈通路之间的动态相互作用产生的。
