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本文引用的文献

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Keratinocytes and cytokines.
Vet Immunol Immunopathol. 2002 Sep 6;88(1-2):1-12. doi: 10.1016/s0165-2427(02)00136-8.
2
Pemphigus vulgaris: the role of IL-1 and IL-1 receptor antagonist in pathogenesis and effects of intravenous immunoglobulin on their production.寻常型天疱疮：白细胞介素-1及白细胞介素-1受体拮抗剂在发病机制中的作用以及静脉注射免疫球蛋白对其产生的影响
Clin Immunol. 2001 Aug;100(2):172-80. doi: 10.1006/clim.2001.5061.
3
Further support for a role for Th2-like cytokines in blister formation of pemphigus.对Th2样细胞因子在天疱疮水疱形成中作用的进一步支持。
Clin Immunol. 2001 Feb;98(2):264-71. doi: 10.1006/clim.2000.4974.
4
The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil. Cooperative Group on Fogo Selvagem Research.巴西地方性落叶型天疱疮中抗桥粒芯糖蛋白1抗体的患病率。灼口综合征研究合作组
N Engl J Med. 2000 Jul 6;343(1):23-30. doi: 10.1056/NEJM200007063430104.
5
Nutritonal evaluation of pemphigus foliaceus patients on long term glucocorticoid therapy.长期接受糖皮质激素治疗的落叶型天疱疮患者的营养评估。
Rev Inst Med Trop Sao Paulo. 2000 Jan-Feb;42(1):23-6. doi: 10.1590/s0036-46652000000100004.
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Desmoglein-1-specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem).来自地方性落叶型天疱疮（fogo selvagem）患者的桥粒芯糖蛋白-1特异性T淋巴细胞。
J Clin Invest. 2000 Jan;105(2):207-13. doi: 10.1172/JCI8075.
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In vitro and in vivo expression of interleukin-1alpha and tumor necrosis factor-alpha mRNA in pemphigus vulgaris: interleukin-1alpha and tumor necrosis factor-alpha are involved in acantholysis.寻常型天疱疮中白细胞介素-1α和肿瘤坏死因子-α mRNA的体外和体内表达：白细胞介素-1α和肿瘤坏死因子-α与棘层松解有关。
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[Autoimmune bullous skin diseases].[自身免疫性大疱性皮肤病]
Rev Med Interne. 1999 Jan;20(1):26-38. doi: 10.1016/s0248-8663(99)83006-9.
9
Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice.抗桥粒芯糖蛋白3（寻常型天疱疮抗原）的抗体存在于副肿瘤性天疱疮患者的血清中，并在新生小鼠体内引起棘层松解。
J Clin Invest. 1998 Aug 15;102(4):775-82. doi: 10.1172/JCI3647.
10
Epidermal adhesion molecules and basement membrane components as target structures of autoimmunity.作为自身免疫靶结构的表皮黏附分子和基底膜成分
Virchows Arch. 1998 Jun;432(6):487-504. doi: 10.1007/s004280050197.

地方性落叶型天疱疮患者体内白细胞介素-1水平升高。

High levels of interleukin-1 in patients with endemic pemphigus foliaceus.

作者信息

Rocha-Rodrigues Denise Bertulucci, Paschoini Giovana, Pereira Sanivia Aparecida Lima, dos Reis Marlene Antonia, Teixeira Vicente de Paula Antunes, Rodrigues Júnior Virmondes

机构信息

Faculdade de Medicina do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.

出版信息

Clin Diagn Lab Immunol. 2003 Sep;10(5):741-3. doi: 10.1128/cdli.10.5.741-743.2003.

DOI:10.1128/cdli.10.5.741-743.2003
PMID:12965897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC193914/
Abstract

Endemic pemphigus foliaceus (EPF) is an autoimmune disease characterized by blister formation with a loss of cohesion and infiltration of inflammatory cells. We observed that supernatants of peripheral blood mononuclear cells from patients produced significantly more interleukin-1beta (IL-1beta) than those from stimulated healthy controls. Furthermore, a Th2 bias was observed in EPF patients when the IL-5/gamma interferon ratio was analyzed. These results indicate that cells from pemphigus patients react with a vigorous proinflammatory response.

摘要

地方性落叶性天疱疮（EPF）是一种自身免疫性疾病，其特征为形成水疱，伴有细胞黏附丧失和炎性细胞浸润。我们观察到，患者外周血单核细胞的上清液产生的白细胞介素-1β（IL-1β）明显多于受刺激的健康对照者。此外，分析IL-5/γ干扰素比值时，在EPF患者中观察到Th2偏向。这些结果表明，天疱疮患者的细胞会产生强烈的促炎反应。