地方性落叶型天疱疮患者体内白细胞介素-1水平升高。
High levels of interleukin-1 in patients with endemic pemphigus foliaceus.
作者信息
Rocha-Rodrigues Denise Bertulucci, Paschoini Giovana, Pereira Sanivia Aparecida Lima, dos Reis Marlene Antonia, Teixeira Vicente de Paula Antunes, Rodrigues Júnior Virmondes
机构信息
Faculdade de Medicina do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
出版信息
Clin Diagn Lab Immunol. 2003 Sep;10(5):741-3. doi: 10.1128/cdli.10.5.741-743.2003.
Abstract
Endemic pemphigus foliaceus (EPF) is an autoimmune disease characterized by blister formation with a loss of cohesion and infiltration of inflammatory cells. We observed that supernatants of peripheral blood mononuclear cells from patients produced significantly more interleukin-1beta (IL-1beta) than those from stimulated healthy controls. Furthermore, a Th2 bias was observed in EPF patients when the IL-5/gamma interferon ratio was analyzed. These results indicate that cells from pemphigus patients react with a vigorous proinflammatory response.
摘要
地方性落叶性天疱疮（EPF）是一种自身免疫性疾病，其特征为形成水疱，伴有细胞黏附丧失和炎性细胞浸润。我们观察到，患者外周血单核细胞的上清液产生的白细胞介素-1β（IL-1β）明显多于受刺激的健康对照者。此外，分析IL-5/γ干扰素比值时，在EPF患者中观察到Th2偏向。这些结果表明，天疱疮患者的细胞会产生强烈的促炎反应。
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