Vitalis Tania, Parnavelas John G
Department of Anatomy and Developmental Biology, University College London, London, UK.
Dev Neurosci. 2003 Mar-Aug;25(2-4):245-56. doi: 10.1159/000072272.
The cerebral cortex is widely innervated by serotonin (5-HT)-containing axons originating from neurons in the raphe nuclei. The early development of this monoamine system in the cortex prompted speculation long ago that it has important functions in cortical maturation and plasticity. Here we review evidence, derived from a plethora of studies and from our recent unpublished work, that supports an important role for 5-HT in a number of major events in the developing cortex, especially at the early stages. This evidence points to a regulatory role for 5-HT in neuronal proliferation, migration and differentiation, and in preventing apoptotic cell death.
大脑皮层广泛地由源自中缝核神经元的含5-羟色胺（5-HT）轴突支配。该单胺系统在皮层中的早期发育早在很久以前就引发了推测，即它在皮层成熟和可塑性方面具有重要功能。在此，我们回顾了来自大量研究以及我们最近未发表工作的证据，这些证据支持5-HT在发育中的皮层的一些主要事件中，尤其是在早期阶段发挥重要作用。这些证据表明5-HT在神经元增殖、迁移和分化以及防止凋亡性细胞死亡方面具有调节作用。
