Manipal Academy of Higher Education, Manipal, India.
National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru, India.
Cell Adh Migr. 2021 Dec;15(1):261-271. doi: 10.1080/19336918.2021.1963574.
Serotonin is well known as a neurotransmitter. Its roles in neuronal processes such as learning, memory or cognition are well established, and also in disorders such as depression, schizophrenia, bipolar disorder, and dementia. However, its effects on adhesion and cytoskeletal remodelling which are strongly affected by 5-HT receptors, are not as well studied with some exceptions for e.g. platelet aggregation. Neuronal function is strongly dependent on cell-cell contacts and adhesion-related processes. Therefore the role played by serotonin in psychiatric illness, as well as in the positive and negative effects of neuropsychiatric drugs through cell-related adhesion can be of great significance. In this review, we explore the role of serotonin in some of these aspects based on recent findings.
血清素是一种众所周知的神经递质。它在学习、记忆或认知等神经元过程中的作用以及在抑郁、精神分裂症、双相情感障碍和痴呆等疾病中的作用已得到充分证实。然而，它对粘附和细胞骨架重塑的影响，而这些影响受 5-HT 受体的强烈影响，除了例如血小板聚集等一些例外情况，研究得并不充分。神经元功能强烈依赖于细胞-细胞接触和粘附相关过程。因此，血清素在精神疾病中的作用以及神经精神药物通过细胞相关粘附产生的正、负面影响都具有重要意义。在这篇综述中，我们根据最近的发现探讨了血清素在其中一些方面的作用。
