Schoenhagen Paul, Tuzcu E Murat, Stillman Arthur E, Moliterno David J, Halliburton Sandra S, Kuzmiak Stacie A, Kasper Jane M, Magyar William A, Lieber Michael L, Nissen Steven E, White Richard D
Department of Radiology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Coron Artery Dis. 2003 Sep;14(6):459-62. doi: 10.1097/00019501-200309000-00007.
Non-invasive identification and characterization of mildly stenotic atherosclerotic lesions is an increasingly important focus of coronary imaging.
We examined the accuracy of multi (16)-slice computed tomography (MSCT) for imaging of these lesions in comparison with intravascular ultrasound (IVUS).
Mildly stenotic segments of the left coronary artery were identified by coronary angiography and analyzed using IVUS and contrast-enhanced MSCT. Independent reviewers evaluated the accuracy of MSCT for presence, composition and distribution of atherosclerotic plaque and remodeling response in comparison to IVUS using receiver operating characteristic (ROC) data analysis.
Of 46 segments in 14 patients, diagnostic characterization by MSCT was possible in 37 (80.4%) segments. In these segments the accuracy of MSCT for identifying plaque presence, calcification, distribution and positive remodeling was consistently greater than 0.90 (reader 1) and 0.87 (reader 2).
State-of-the-art MSCT can accurately identify mildly stenotic coronary atherosclerosis and provide an assessment of morphology and remodeling response.
轻度狭窄动脉粥样硬化病变的无创识别与特征描述是冠状动脉成像日益重要的重点。
我们将多层（16层）计算机断层扫描（MSCT）与血管内超声（IVUS）相比较，检测其对这些病变成像的准确性。
通过冠状动脉造影识别左冠状动脉的轻度狭窄节段，并使用IVUS和对比增强MSCT进行分析。独立评估者使用接受者操作特征（ROC）数据分析，将MSCT在动脉粥样硬化斑块的存在、成分和分布以及重塑反应方面的准确性与IVUS进行比较。
在14例患者的46个节段中，37个（80.4%）节段可通过MSCT进行诊断特征描述。在这些节段中，MSCT识别斑块存在、钙化、分布和正向重塑的准确性始终大于0.90（阅读者1）和0.87（阅读者2）。
先进的MSCT能够准确识别轻度狭窄的冠状动脉粥样硬化，并对形态和重塑反应进行评估。
