Derk Chris T, Sakkas Lazaros I, Rasheed Mehmoodur, Artlett Carol, Jimenez Sergio A
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, 233 South 10th Street, 509 BLSB, Philadelphia, PA 19107, USA.
J Rheumatol. 2003 Sep;30(9):1994-6.
To determine the prevalence of specific autoantibodies in a cohort of patients with systemic sclerosis (SSc) and a diagnosis of cancer, and to compare it to that in a group of patients with SSc who were never diagnosed with cancer.
From 769 patients with SSc followed at our center over the past 15 years, 77 had a diagnosis of cancer. The results of autoantibody studies in this group were compared to those from 159 SSc patients without cancer randomly selected from the rest of the patient population using chi-square test for independence and the null hypothesis for 2 population proportions.
There was no statistically significant difference between the proportions of patients with positive autoantibodies between the 2 groups, except that a higher prevalence of autoantibodies with a nucleolar immunofluorescence pattern was observed in the group of patients who were never diagnosed with cancer (p < 0.01).
In contrast to previous studies, in our case-control study we were not able to detect a significant difference in autoantibody frequency or patterns among SSc patients with and without a diagnosis of cancer. These results refute the conclusion made previously that certain autoantibodies may represent risk factors for the development of cancer in patients with SSc.
确定一组患有系统性硬化症（SSc）且已诊断出癌症的患者中特定自身抗体的患病率，并将其与一组从未被诊断出患有癌症的SSc患者的患病率进行比较。
在过去15年中，我们中心随访的769例SSc患者中，有77例被诊断出患有癌症。使用独立性卡方检验和两个总体比例的零假设，将该组自身抗体研究结果与从其余患者人群中随机选择的159例无癌症的SSc患者的结果进行比较。
两组之间自身抗体阳性患者的比例没有统计学上的显著差异，只是在从未被诊断出患有癌症的患者组中观察到核仁免疫荧光模式的自身抗体患病率更高（p<0.01）。
与先前的研究相反，在我们的病例对照研究中，我们未能检测出已诊断和未诊断出癌症的SSc患者在自身抗体频率或模式上的显著差异。这些结果驳斥了先前得出的某些自身抗体可能代表SSc患者患癌风险因素的结论。
