Derk Chris T, Rasheed Mehmoodur, Artlett Carol M, Jimenez Sergio A
Division of Rhematology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
J Rheumatol. 2006 Jun;33(6):1113-6. Epub 2006 Mar 15.
To describe the incidence of cancer in a large cohort of patients with systemic sclerosis (SSc) and compare it to the Surveillance Epidemiology and End Results (SEER) cancer registries.
Cancer risk in a large cohort of patients with SSc followed at our institution was assessed. A total of 769 patients with SSc who were followed between 1987 and 2002 were screened for the development of cancer. Standardized incidence ratios (SIR) for malignancies identified after diagnosis of SSc were calculated using the SEER cancer registries and stratified by sex.
Ninety malignancies were diagnosed in 769 patients followed at our institution between 1987 and 2002. Sixty-two malignancies were diagnosed after diagnosis of SSc in a total of 3,775 patient years of followup. Twenty-eight malignancies were diagnosed prior to diagnosis of SSc. The SIR for all cancers diagnosed after diagnosis of SSc was 1.55 (1.16-1.93). The SIR for esophageal cancer was 15.9 (4.2-27.6) while that of oropharyngeal cancer was 9.63 (2.97-16.29).
We identified an overall increase in the incidence of cancer in a cohort of patients with SSc compared to the general population, with statistically significant differences in the incidence of esophageal and oropharyngeal cancers.
描述一大群系统性硬化症（SSc）患者的癌症发病率，并将其与监测、流行病学和最终结果（SEER）癌症登记处的数据进行比较。
评估了在我们机构随访的一大群SSc患者的癌症风险。对1987年至2002年间随访的769例SSc患者进行了癌症发生情况筛查。使用SEER癌症登记处的数据计算SSc诊断后确诊的恶性肿瘤的标准化发病率（SIR），并按性别分层。
1987年至2002年间在我们机构随访的769例患者中诊断出90例恶性肿瘤。在总共3775人年的随访中，SSc诊断后有62例恶性肿瘤被诊断出来。28例恶性肿瘤在SSc诊断之前被诊断出来。SSc诊断后确诊的所有癌症的SIR为1.55（1.16 - 1.93）。食管癌的SIR为15.9（4.2 - 27.6），而口咽癌的SIR为9.63（2.97 - 16.29）。
我们发现与普通人群相比，SSc患者队列中的癌症发病率总体上升，食管癌和口咽癌的发病率存在统计学上的显著差异。
