Denmark Scott E, Kallemeyn Jeffrey M
Roger Adams Laboratory, Department of Chemistry, University of Illinois, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA.
Org Lett. 2003 Sep 18;5(19):3483-6. doi: 10.1021/ol035288m.
[reaction: see text] A mild and general palladium-catalyzed insertion of 1,2-diethoxy-1,1,2,2-tetramethyldisilane into a variety of aryl bromides affords the aryldimethylsilyl ethers in high yields. Hydrolysis of the ethers under pH-optimized conditions results in the exclusive formation of the desired aryldimethylsilanols.
[反应：见正文] 在温和且通用的钯催化下，1,2 - 二乙氧基 - 1,1,2,2 - 四甲基二硅烷插入到多种芳基溴化物中，能以高产率得到芳基二甲基甲硅烷基醚。在pH优化的条件下对醚进行水解，专一性地生成所需的芳基二甲基硅醇。
