侵袭性A组链球菌病：成人的危险因素。
Invasive group A streptococcal disease: risk factors for adults.
作者信息
Factor Stephanie H, Levine Orin S, Schwartz Benjamin, Harrison Lee H, Farley Monica M, McGeer Allison, Schuchat Anne
机构信息
Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
Emerg Infect Dis. 2003 Aug;9(8):970-7. doi: 10.3201/eid0908.020745.
We conducted a case-control study to identify risk factors for invasive group A streptococcal (GAS) infections, which can be fatal. Case-patients were identified when Streptococcus pyogenes was isolated from a normally sterile site and control subjects (two or more) were identified and matched to case-patients by using sequential-digit telephone dialing. All participants were noninstitutionalized surveillance area residents, >18 years of age. Conditional logistic regression identified the risk factors for invasive GAS infection: in adults 18 to 44 years of age, exposure to one or more children with sore throats (relative risk [RR]=4.93, p=0.02), HIV infection (RR=15.01, p=0.04), and history of injecting drug use (RR=14.71, p=0.003); in adults >45 years of age, number of persons in the home (RR=2.68, p=0.004), diabetes (RR=2.27, p=0.03), cardiac disease (RR=3.24, p=0.006), cancer (RR=3.54, p=0.006), and corticosteroid use (RR=5.18, p=0.03). Thus, host and environmental factors increased the risk for invasive GAS disease.
我们开展了一项病例对照研究，以确定可致命的侵袭性A组链球菌（GAS）感染的危险因素。当从通常无菌的部位分离出化脓性链球菌时确定病例患者，并通过连续数字电话拨号确定对照对象（两名或更多）并与病例患者进行匹配。所有参与者均为非机构化监测区域居民，年龄大于18岁。条件逻辑回归确定了侵袭性GAS感染的危险因素：在18至44岁的成年人中，接触一名或多名咽痛儿童（相对风险[RR]=4.93，p=0.02）、HIV感染（RR=15.01，p=0.04）以及注射吸毒史（RR=14.71，p=0.003）；在45岁以上的成年人中，家庭人口数（RR=2.68，p=0.004）、糖尿病（RR=2.27，p=0.03）、心脏病（RR=3.24，p=0.006）、癌症（RR=3.54，p=0.006）以及使用皮质类固醇（RR=5.18，p=0.03）。因此，宿主和环境因素增加了侵袭性GAS疾病的风险。
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