Poikonen Eira, Lyytikäinen Outi, Anttila Veli-Jukka, Ruutu Petri
Peijas Hospital, Vantaa, Finland.
Emerg Infect Dis. 2003 Aug;9(8):985-90. doi: 10.3201/eid0908.030069.
We analyzed laboratory-based surveillance candidemia data from the National Infectious Disease Register in Finland and reviewed cases of candidemia from one tertiary-care hospital from 1995 to 1999. A total of 479 candidemia cases were reported to the Register. The annual incidence rose from 1.7 per 100,000 population in 1995 to 2.2 in 1999. Species other than Candida albicans accounted for 30% of cases without change in the proportion. A total of 79 cases of candidemia were identified at the hospital; the rate varied from 0.03 to 0.05 per 1,000 patient-days by year. Predisposing factors included indwelling catheters (81%), gastrointestinal surgery (27%), hematologic malignancy (25%), other types of surgery (21%), and solid malignancies (20%). Crude 7-day and 30-day case-fatality ratios were 15% and 35%, respectively. The rate of candidemia increased in Finland but is still substantially lower than in the United States. No shift to non-C. albicans species could be detected.
我们分析了来自芬兰国家传染病登记处基于实验室监测的念珠菌血症数据，并回顾了一家三级护理医院1995年至1999年期间的念珠菌血症病例。共有479例念珠菌血症病例上报至该登记处。年发病率从1995年的每10万人1.7例升至1999年的每10万人2.2例。白色念珠菌以外的其他菌种占病例的30%，比例未变。该医院共确诊79例念珠菌血症病例；每年每1000个患者日的发病率在0.03至0.05之间。诱发因素包括留置导管（81%）、胃肠道手术（27%）、血液系统恶性肿瘤（25%）、其他类型手术（21%）和实体恶性肿瘤（20%）。7天和30天的粗病死率分别为15%和35%。芬兰的念珠菌血症发病率有所上升，但仍远低于美国。未发现向非白色念珠菌菌种的转变。
