Duff K, Parsons J, Hodgman T C
Department of Medicine, University of Cambridge, UK.
DNA Seq. 1992;3(4):213-20. doi: 10.3109/10425179209034020.
The predicted protein product of an anonymous clone isolated from a cDNA library prepared from 12 day post coitum (p.c) embryonic mouse heart tissue demonstrated the same segmental repeats previously identified in the cell division control protein, CDC4 and the G protein beta 1 subunit. A search of the protein database subsequently identified three other classes of protein containing the repeat. Secondary structure analyses performed on the repeat sequences revealed a high degree of conservation suggesting that the repeat motif performs a specific function in a diverse range of proteins.
从交配后12天（p.c）的胚胎小鼠心脏组织制备的cDNA文库中分离出的一个无名克隆的预测蛋白质产物，显示出与先前在细胞分裂控制蛋白CDC4和G蛋白β1亚基中鉴定出的相同的片段重复。随后在蛋白质数据库中进行的搜索又鉴定出另外三类含有该重复序列的蛋白质。对这些重复序列进行的二级结构分析显示出高度的保守性，这表明该重复基序在多种蛋白质中发挥特定功能。
