Eskenasy A, Eskenasy M
Morphol Embryol (Bucur). 1975;21(2):149-55.
During a prolonged exposure of rabbits to aerosols with asperigillary antigens, the content of bronchial and bronchiolar epithelia in mucus-secreting cells was quantified. In normals, the mucous cells do not exceed 3.2 per cent in bronchial epithelium and 0.44 per cent in bronchiolar one. After exposure, these proportions rapidly increase, after a primary discharge of goblet cells. The mucous cells become a majority after 7 exposures in bronchi and after 21 in bronchiolar epithelium. The maturation is more rapid in bronchioli than in bronchi. The secretion of neutral and acid mucopolysaccharides is early, concomitant in the same bronchus, and predominantly located in the impingement zones, especially the bifurcations of bronchial tree. The mitoses are extremely rare in exposed bronchi, but the epithelial and mesenchymal alveolar cells present a high mitotic index (1.14%) 24 hours after the second exposure to antigens.
在兔子长时间暴露于含有曲霉抗原的气溶胶的过程中，对支气管和细支气管上皮中黏液分泌细胞的含量进行了定量分析。在正常情况下，黏液细胞在支气管上皮中不超过3.2%，在细支气管上皮中不超过0.44%。暴露后，在杯状细胞初次排出后，这些比例迅速增加。在支气管中经过7次暴露后，黏液细胞成为多数，在细支气管上皮中经过21次暴露后亦是如此。细支气管中的成熟比支气管中更快。中性和酸性黏多糖的分泌较早，在同一支气管中同时出现，且主要位于撞击区域，尤其是支气管树的分支处。在暴露的支气管中，有丝分裂极为罕见，但在第二次接触抗原24小时后，上皮和间充质肺泡细胞呈现出较高的有丝分裂指数（1.14%）。
