[高频通气时气管和肺形态学变化的动物实验研究]
[Animal experiment studies of morphologic changes in the trachea and lung in high frequency ventilation].
作者信息
Eckert H, Danzmann E, Voigt H, Oddoy A, Merker G, Harzendorf E, Bomm M, Noack K, Ritzau E
机构信息
Forschungsinstitut für Lungenkrankheiten und Tuberkulose, Berlin-Buch/DDR.
出版信息
Z Erkr Atmungsorgane. 1988;170(2):172-8.
PMID:3400290
Abstract
Prolonged high frequency ventilation (24 hrs) in dogs leads to morphological changes in the trachea as well as in the bronchi. Erosive changes of tracheal epithelium were observed whereas small bronchi and bronchioli exhibited luminal obstructions by mucus plugs, caused by hypersecretion of goblet cells. Using histochemical methods degenerative changes of bronchiolar epithelium were observed.
摘要
犬长时间高频通气（24小时）会导致气管以及支气管出现形态学变化。观察到气管上皮有糜烂性改变，而小支气管和细支气管则出现黏液栓导致的管腔阻塞，这是由杯状细胞分泌亢进引起的。采用组织化学方法观察到细支气管上皮有退行性变化。
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