Nemirovskaia T L, Shenkman B S, Mukhina A M, Volodkovich Ia Iu, Saiapina M M, Brattseva E V, Larina O M
Institute of Medical-Biological Problems, Russian Acad. Sci., Russia, 123007, Moscow, 76a Khoroshevskoe Shosse.
Ross Fiziol Zh Im I M Sechenova. 2003 Mar;89(3):259-70.
The study was purposed to evaluate the contribution of the reflectory and local components during the chronic stretch of the postural muscle to the attenuation of the unloading-induced fiber size reduction and changes in the myosin heavy chain (MHC) profile. The surgical unilateral deafferentation (dorsal rhizotomy) was used. It was shown that unilateral deafferentation didn't influence on the amelioration of unloading-induced fiber size reduction in chronically stretched soleus muscle. Thus, the results obtained in the present study don't confirm the hypothesis, supposing the predominant contribution of the muscle afferent activation to the attenuation of unloading-induced fiber atrophy. Deafferentation of unloaded as well as control rats leads to the increase of the percentage of fibers expressing slow MYC isoforms.
本研究旨在评估姿势肌慢性拉伸过程中反射性和局部成分对卸载诱导的纤维尺寸减小和肌球蛋白重链（MHC）谱变化的衰减作用。采用手术单侧去传入神经（背根切断术）。结果表明，单侧去传入神经对慢性拉伸的比目鱼肌中卸载诱导的纤维尺寸减小的改善没有影响。因此，本研究获得的结果不支持肌肉传入神经激活对卸载诱导的纤维萎缩衰减起主要作用的假设。卸载大鼠和对照大鼠的去传入神经均导致表达慢肌球蛋白亚型的纤维百分比增加。
