Nemirovskaya T L, Shenkman B S, Mukhina A M, Volodkovich Ya Yu, Sayapina M M, Brattseva E, Larina O
State Scientific Center of the Russian Federation/Institute of Medical-Biological Problems, Russian Academy of Sciences, 761 Khoroshevskoe Chaussee, 123007 Moscow, Russia.
Neurosci Behav Physiol. 2004 Sep;34(7):755-63. doi: 10.1023/b:neab.0000036018.18505.3e.
The aim of the present work was to assess the contributions of the reflex and local components to preventing decreases in the size and changes in the ratio of fibers containing the slow and fast isoforms of myosin heavy chains during chronic stretching of a postural muscle in rats in conditions of gravitational unloading. A unilateral surgical deafferentation method was used. The results demonstrated that deafferentation of the hindlimb had no effect on preventing reductions in muscle fiber size in conditions of chronic muscle stretching in conditions of gravitational unloading. The results obtained from these experiments did not support the hypothesis that the predominant contribution to preventing the development of atrophic changes comes from activation of muscle afferents in chronic stretching of the unloaded muscle. Deafferentation of both suspended animals and those with normal motor activity led to increases in the proportion of soleus muscle fibers containing the slow isoforms of myosin heavy chain.
本研究的目的是评估在大鼠姿势性肌肉慢性拉伸且处于重力卸载条件下，反射和局部成分对防止肌纤维大小减小以及含有慢肌球蛋白重链和快肌球蛋白重链亚型的纤维比例变化的作用。采用了单侧手术去传入神经方法。结果表明，在重力卸载条件下慢性肌肉拉伸时，后肢去传入神经对防止肌纤维大小减小没有影响。从这些实验中获得的结果不支持以下假设：在卸载肌肉的慢性拉伸中，防止萎缩性变化发展的主要贡献来自肌肉传入神经的激活。对悬吊动物和具有正常运动活动的动物进行去传入神经处理，均导致比目鱼肌中含有慢肌球蛋白重链亚型的纤维比例增加。
