Detamore Michael S, Athanasiou Kyriacos A
Department of Bioengineering, Rice University, Houston, TX 77251, USA.
J Biomech Eng. 2003 Aug;125(4):558-65. doi: 10.1115/1.1589778.
Despite the significant morbidity associated with the temporomandibular joint (TMJ), little is known about the pathophysiology of this complex joint. TMJ disc degeneration plays a central role in the progression of TMJ disorders, and therefore disc regeneration would be a crucial treatment modality. Unfortunately, scarce information about the structural and functional characteristics of the TMJ disc is available. The current study aims to provide a standard for the biomechanical behavior of the TMJ disc for future tissue engineering studies. The disc was loaded under uniaxial tension in two directions, mediolateral and anteroposterior, and in three locations per direction. In the mediolateral direction, the posterior band was 2.5 times stiffer, 2.4 times tougher (energy to maximum stress), and 2.2 times stronger than the anterior band, which was in turn 16 times stiffer and 5.7 times stronger than the intermediate zone. In the anteroposterior direction, the central and medial regions were 74% and 35% stiffer and 56% and 59% stronger than the lateral region, respectively, although similar to each other in strength and stiffness. There was no significant difference in toughness between regions in the anteroposterior direction. These results correlated qualitatively with collagen fiber orientation and fiber size obtained using polarized light microscopy.
尽管颞下颌关节（TMJ）相关的发病率很高，但对于这个复杂关节的病理生理学却知之甚少。TMJ盘退变在TMJ疾病的进展中起核心作用，因此盘再生将是一种关键的治疗方式。不幸的是，关于TMJ盘的结构和功能特征的信息很少。当前的研究旨在为未来的组织工程研究提供TMJ盘生物力学行为的标准。在两个方向上对盘进行单轴拉伸加载，即内外侧方向和前后方向，每个方向在三个位置进行加载。在内外侧方向上，后带的刚度是前带的2.5倍，韧性（至最大应力的能量）是前带的2.4倍，强度是前带的2.2倍，而前带的刚度又是中间带的16倍，强度是中间带的5.7倍。在前后方向上，中央区域和内侧区域的刚度分别比外侧区域高74%和35%，强度分别比外侧区域高56%和59%，尽管它们在强度和刚度方面彼此相似。在前后方向上，各区域之间的韧性没有显著差异。这些结果与使用偏光显微镜获得的胶原纤维取向和纤维大小在质量上相关。
