Desta Abiy B, Owen Russell D, Cress Larry W
US Food and Drug Administration, 9200 Corporate Blvd, Rockville, Maryland 20850, USA.
Radiat Res. 2003 Oct;160(4):488-91. doi: 10.1667/rr3054.
L929 murine fibroblast cells were exposed to radiofrequency (RF) radiation from a time division multiple access wireless phone operating at 835 MHz frequency to determine the effect of RF-radiation energy emitted by wireless phones on ornithine decarboxylase (ODC) activity in cultured cells. Exposure was for 8 h to an average specific absorption rate (SAR) from <1 W/kg up to 15 W/kg. After exposure, cells were harvested and ODC activity was measured. No statistically significant difference in ODC activity was found between RF-radiation-exposed and sham-exposed cells at non-thermal specific absorption rates. At SARs which resulted in measurable heating of the medium, a dose-dependent decrease in enzymatic activity was observed and was shown to be consistent with a comparable decrease caused by non-RF-radiation heating. Thus we observed only the well-known enzyme inhibition due to heating, rather than the previously reported enhancement attributed to RF-radiation exposure.
将L929小鼠成纤维细胞暴露于一部工作频率为835兆赫兹的时分多址无线电话发出的射频（RF）辐射中，以确定无线电话发出的RF辐射能量对培养细胞中鸟氨酸脱羧酶（ODC）活性的影响。暴露时间为8小时，平均比吸收率（SAR）从小于1瓦/千克到15瓦/千克。暴露后，收获细胞并测量ODC活性。在非热比吸收率下，RF辐射暴露组和假暴露组细胞的ODC活性未发现统计学上的显著差异。在导致培养基可测量加热的SAR下，观察到酶活性呈剂量依赖性下降，并且显示出与非RF辐射加热引起的可比下降一致。因此，我们仅观察到了因加热导致的众所周知的酶抑制作用，而非先前报道的归因于RF辐射暴露的增强作用。
