Müller Gerd, Höpken Uta E, Lipp Martin
Department of Molecular Tumor Genetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany.
Immunol Rev. 2003 Oct;195:117-35. doi: 10.1034/j.1600-065x.2003.00073.x.
The development of secondary lymphoid organs is a complex process dependent on a coordinated interaction of cells of hematopoietic and non-hematopoietic origin. In this context, chemokines and cytokines belonging to the tumor necrosis factor (TNF)/lymphotoxin (LT) family are critical signaling molecules during the initial steps of lymph node and Peyer's patch organogenesis. Homeostatic chemokines, such as CXCL13, CCL21, and CCL19, as well as their corresponding receptors, CXCR5 and CCR7, have now been shown to closely cooperate in the development of lymphoid organs and the maintenance of lymphoid tissue microarchitecture. We summarize recent data on the function of CXCR5 and CCR7 and their intricate connection to the TNF/LT system in order to refine the current model of lymphoid organ development.
次级淋巴器官的发育是一个复杂的过程，依赖于造血和非造血来源细胞的协同相互作用。在这种情况下，属于肿瘤坏死因子（TNF）/淋巴毒素（LT）家族的趋化因子和细胞因子是淋巴结和派尔集合淋巴结器官发生初始阶段的关键信号分子。稳态趋化因子，如CXCL13、CCL21和CCL19，以及它们相应的受体CXCR5和CCR7，现已证明在淋巴器官发育和淋巴组织微结构维持中密切协作。我们总结了关于CXCR5和CCR7功能及其与TNF/LT系统复杂联系的最新数据，以完善当前的淋巴器官发育模型。
