由于多原核卵母细胞导致体外受精失败后成功进行胞浆内单精子注射。
Successful intracytoplasmic sperm injection after failed in vitro fertilization due to multipronuclear oocytes.
作者信息
van der Westerlaken Lucette, Helmerhorst Frans, Verburg Harjo, Naaktgeboren Nico
机构信息
Department of Reproductive Medicine, Leiden University Medical Centre, Leiden, The Netherlands.
出版信息
Fertil Steril. 2003 Sep;80(3):639-40. doi: 10.1016/s0015-0282(03)00752-0.
OBJECTIVE
To report a case of IVF with apparently normal female and male gametes that resulted in the development of only multipronuclear oocytes (instead of oocytes containing two pronuclei) and was successfully treated with ICSI.
DESIGN
Case report.
SETTING
A university hospital.
PATIENT(S): A 35-year-old woman with unexplained infertility and her partner, a 38-year-old man with normozoospermia.
INTERVENTION(S): Intracytoplasmic sperm injection.
MAIN OUTCOME MEASURE(S): Oocyte fertilization and pregnancy.
RESULT(S): Normal fertilization and an ongoing pregnancy occurred after transfer of two embryos.
CONCLUSION(S): Although the usual indication for ICSI is male subfertility, it can also be used to successfully treat oocyte defects.
目的
报告一例体外受精（IVF）病例，该病例中雌雄配子表面看似正常，但仅发育出多原核卵母细胞（而非含有两个原核的卵母细胞），并通过卵胞浆内单精子注射（ICSI）成功治疗。
设计
病例报告。
地点
一家大学医院。
患者
一名35岁不明原因不孕的女性及其伴侣，一名38岁精子正常的男性。
干预措施
卵胞浆内单精子注射。
主要观察指标
卵母细胞受精和妊娠情况。
结果
移植两个胚胎后实现了正常受精并成功妊娠。
结论
虽然ICSI的常见适应症是男性生育力低下，但它也可用于成功治疗卵母细胞缺陷。
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