van der Westerlaken Lucette, Helmerhorst Frans, Verburg Harjo, Naaktgeboren Nico
Department of Reproductive Medicine, Leiden University Medical Centre, Leiden, The Netherlands.
Fertil Steril. 2003 Sep;80(3):639-40. doi: 10.1016/s0015-0282(03)00752-0.
To report a case of IVF with apparently normal female and male gametes that resulted in the development of only multipronuclear oocytes (instead of oocytes containing two pronuclei) and was successfully treated with ICSI.
Case report.
A university hospital.
PATIENT(S): A 35-year-old woman with unexplained infertility and her partner, a 38-year-old man with normozoospermia.
INTERVENTION(S): Intracytoplasmic sperm injection.
MAIN OUTCOME MEASURE(S): Oocyte fertilization and pregnancy.
RESULT(S): Normal fertilization and an ongoing pregnancy occurred after transfer of two embryos.
CONCLUSION(S): Although the usual indication for ICSI is male subfertility, it can also be used to successfully treat oocyte defects.
报告一例体外受精（IVF）病例，该病例中雌雄配子表面看似正常，但仅发育出多原核卵母细胞（而非含有两个原核的卵母细胞），并通过卵胞浆内单精子注射（ICSI）成功治疗。
病例报告。
一家大学医院。
一名35岁不明原因不孕的女性及其伴侣，一名38岁精子正常的男性。
卵胞浆内单精子注射。
卵母细胞受精和妊娠情况。
移植两个胚胎后实现了正常受精并成功妊娠。
虽然ICSI的常见适应症是男性生育力低下，但它也可用于成功治疗卵母细胞缺陷。
